Now showing items 1-4 of 4
Leptin metabolically licenses T cells for activation to link nutrition and immunity.
(J Immunol, 2014-01-01)
Immune responses are highly energy-dependent processes. Activated T cells increase glucose uptake and aerobic glycolysis to survive and function. Malnutrition and starvation limit nutrients and are associated with immune ...
Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets.
(J Immunol, 2011-03-15)
Stimulated CD4(+) T lymphocytes can differentiate into effector T cell (Teff) or inducible regulatory T cell (Treg) subsets with specific immunological roles. We show that Teff and Treg require distinct metabolic programs ...
The liver kinase B1 is a central regulator of T cell development, activation, and metabolism.
(J Immunol, 2011-10-15)
T cell activation leads to engagement of cellular metabolic pathways necessary to support cell proliferation and function. However, our understanding of the signal transduction pathways that regulate metabolism and their ...
Engineering a BCR-ABL-activated caspase for the selective elimination of leukemic cells.
(Proc Natl Acad Sci U S A, 2013-02-05)
Increased understanding of the precise molecular mechanisms involved in cell survival and cell death signaling pathways offers the promise of harnessing these molecules to eliminate cancer cells without damaging normal cells. ...