Now showing items 1-10 of 18
Analysis of the mouse transcriptome for genes involved in the function of the nervous system.
(Genome Res, 2003-06)
We analyzed the mouse Representative Transcript and Protein Set for molecules involved in brain function. We found full-length cDNAs of many known brain genes and discovered new members of known brain gene families, including ...
Influence of network topology and data collection on network inference.
(Pac Symp Biocomput, 2003)
We recently developed an approach for testing the accuracy of network inference algorithms by applying them to biologically realistic simulations with known network topology. Here, we seek to determine the degree to which ...
A functional analysis of the spacer of V(D)J recombination signal sequences.
(PLoS Biol, 2003-10)
During lymphocyte development, V(D)J recombination assembles antigen receptor genes from component V, D, and J gene segments. These gene segments are flanked by a recombination signal sequence (RSS), which serves as the ...
The role of the thalamus in motor control.
(Curr Opin Neurobiol, 2003-12)
Two characteristics of the thalamus--its apparently simple relay function and its daunting multinuclear structure--have been customarily viewed as good reasons to study something else. Yet, now that many other brain regions ...
beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi.
(Proc Natl Acad Sci U S A, 2003-02-04)
Phosphorylation of the beta(2) adrenoreceptor (beta(2)AR) by cAMP-activated protein kinase A (PKA) switches its predominant coupling from stimulatory guanine nucleotide regulatory protein (G(s)) to inhibitory guanine nucleotide ...
Faces evoke spatially differentiated patterns of BOLD activation and deactivation.
Using fMRI techniques sensitive to blood oxygen-level dependent (BOLD) contrast, we measured brain activity in participants (n=8) as they viewed images of faces presented periodically within a continuously changing montage ...
Prospective estimation of recombination signal efficiency and identification of functional cryptic signals in the genome by statistical modeling.
(J Exp Med, 2003-01-20)
The recombination signals (RS) that guide V(D)J recombination are phylogenetically conserved but retain a surprising degree of sequence variability, especially in the nonamer and spacer. To characterize RS variability, we ...
The Dialogue Between Cerebral Cortex and Superior Colliculus: Implications for Saccadic Target Selection and Corollary Discharge
(The Visual Neurosciences, 2003)
The frontal eye field sends predictively remapped visual signals to the superior colliculus
(Journal of Vision, 2003-12-01)
We perceive a stable visual world even though saccades often move our retinas. One way the brain may achieve a stable visual percept is through predictive remapping of visual receptive fields: just before a saccade, the ...
Enhanced rewarding properties of morphine, but not cocaine, in beta(arrestin)-2 knock-out mice.
(J Neurosci, 2003-11-12)
The reinforcing and psychomotor effects of morphine involve opiate stimulation of the dopaminergic system via activation of mu-opioid receptors (muOR). Both mu-opioid and dopamine receptors are members of the G-protein-coupled ...