Now showing items 1-10 of 102
Thousands of human mobile element fragments undergo strong purifying selection near developmental genes.
(Proceedings of the National Academy of Sciences of the United States of America, 2007-05)
At least 5% of the human genome predating the mammalian radiation is thought to have evolved under purifying selection, yet protein-coding and related untranslated exons occupy at most 2% of the genome. Thus, the majority ...
Strategic use of statistical thinking in drug development.
(Stat Med, 2000-12-15)
The role of the statistician and statistical thinking in the pharmaceutical industry has evolved greatly in the last four or five decades. Regulatory developments and the changing face of the science of drug development ...
Differentiating sensitivity of post-stimulus undershoot under diffusion weighting: implication of vascular and neuronal hierarchy.
(PLoS One, 2008-08-13)
The widely used blood oxygenation level dependent (BOLD) signal during brain activation, as measured in typical fMRI methods, is composed of several distinct phases, the last of which, and perhaps the least understood, is ...
Perceived discrimination and health: a meta-analytic review.
(Psychol Bull, 2009-07)
Perceived discrimination has been studied with regard to its impact on several types of health effects. This meta-analysis provides a comprehensive account of the relationships between multiple forms of perceived discrimination ...
Analysis of the mouse transcriptome for genes involved in the function of the nervous system.
(Genome Res, 2003-06)
We analyzed the mouse Representative Transcript and Protein Set for molecules involved in brain function. We found full-length cDNAs of many known brain genes and discovered new members of known brain gene families, including ...
Polyclonal B cell differentiation and loss of gastrointestinal tract germinal centers in the earliest stages of HIV-1 infection.
(PLoS Med, 2009-07-07)
BACKGROUND: The antibody response to HIV-1 does not appear in the plasma until approximately 2-5 weeks after transmission, and neutralizing antibodies to autologous HIV-1 generally do not become detectable until 12 weeks ...
Influence of network topology and data collection on network inference.
(Pac Symp Biocomput, 2003)
We recently developed an approach for testing the accuracy of network inference algorithms by applying them to biologically realistic simulations with known network topology. Here, we seek to determine the degree to which ...
Clinical trials registration.
(PLoS Med, 2006-03)
Metronomic chemotherapy with daily, oral etoposide plus bevacizumab for recurrent malignant glioma: a phase II study.
(Br J Cancer, 2009-12-15)
BACKGROUND: We evaluated bevacizumab with metronomic etoposide among recurrent malignant glioma patients in a phase 2, open-label trial. METHODS: A total of 59 patients, including 27 with glioblastoma (GBM) and 32 with grade ...
Corollary discharge circuits in the primate brain.
(Curr Opin Neurobiol, 2008-12)
Movements are necessary to engage the world, but every movement results in sensorimotor ambiguity. Self-movements cause changes to sensory inflow as well as changes in the positions of objects relative to motor effectors ...