Now showing items 1-10 of 200
Functional Relevance of Improbable Antibody Mutations for HIV Broadly Neutralizing Antibody Development.
(Cell host & microbe, 2018-06)
HIV-1 broadly neutralizing antibodies (bnAbs) require high levels of activation-induced cytidine deaminase (AID)-catalyzed somatic mutations for optimal neutralization potency. Probable mutations occur at sites of frequent ...
Differences between completely physically inactive and low active older men and their response to an exercise intervention: the Veterans LIFE study.
(Healthy aging research, 2015-01)
Physical activity interventions typically do not report behavioral changes in activity sub-groups. The aim of this study was to compare baseline differences and changes in physical activity between truly physically inactive ...
The Warrior Wellness Study: A Randomized Controlled Exercise Trial for Older Veterans with PTSD.
(Translational journal of the American College of Sports Medicine, 2018-03)
Posttraumatic stress disorder (PTSD) affects up to 30% of military veterans. Older veterans, many of whom have lived with PTSD symptoms for several decades, report a number of negative health outcomes. Despite the demonstrated ...
Tenascin-C is an innate broad-spectrum, HIV-1-neutralizing protein in breast milk.
(Proceedings of the National Academy of Sciences of the United States of America, 2013-11)
Achieving an AIDS-free generation will require elimination of postnatal transmission of HIV-1 while maintaining the nutritional and immunologic benefits of breastfeeding for infants in developing regions. Maternal/infant ...
A Testosterone Metabolite 19-Hydroxyandrostenedione Induces Neuroendocrine Trans-Differentiation of Prostate Cancer Cells via an Ectopic Olfactory Receptor.
(Frontiers in oncology, 2018-01)
Olfactory receptor OR51E2, also known as a Prostate Specific G-Protein Receptor, is highly expressed in prostate cancer but its function is not well understood. Through in silico and in vitro analyses, we identified 24 agonists ...
Neurological Sequelae and Clinical Outcomes After Lung Transplantation.
(Transplantation direct, 2018-04)
Neurological complications are common after lung transplantation. However, no large cohort studies have examined the incidence, predictors, and clinical significance of neurological events sustained by lung transplant ...
Managing incidental genomic findings in clinical trials: fulfillment of the principle of justice.
(PLoS medicine, 2014-01-14)
Molecular genetic testing and the future of clinical genomics.
(Nature reviews. Genetics, 2013-06)
Genomic technologies are reaching the point of being able to detect genetic variation in patients at high accuracy and reduced cost, offering the promise of fundamentally altering medicine. Still, although scientists and ...
Educating future providers of personalized medicine.
(North Carolina medical journal, 2013-11)
Participant-Partners in Genetic Research: An Exome Study with Families of Children with Unexplained Medical Conditions
(Journal of Participatory Medicine, 2018)