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Staphylococcus aureus bacteraemia in a tropical setting: Patient outcome and impact of antibiotic resistance 

Becher, H; Chierakul, W; Day, NP; Fowler, Vance G Jr; Hongsuwan, M; Limmathurotsakul, D; Mahavanakul, W; ... (16 authors) (PLoS ONE, 2009)
Background: Most information on invasive Staphylococcus aureus infections comes from temperate countries. There are considerable knowledge gaps in epidemiology, treatment, drug resistance and outcome of invasive S. aureus ...
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Construct and differential item functioning in the assessment of prescription opioid use disorders among American adolescents. 

Wu, Li-Tzy; Ringwalt, Christopher L; Yang, Chongming; Reeve, Bryce B; Pan, Jeng-Jong; Blazer, Dan G (Journal of the American Academy of Child and Adolescent Psychiatry, 2009-05)
OBJECTIVE:To examine the psychometric properties of diagnostic criteria for prescription analgesic opioid use disorders (OUDs) and to identify background predictors of a latent continuum for OUD liability. METHOD:Data were ...
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Polyclonal B cell differentiation and loss of gastrointestinal tract germinal centers in the earliest stages of HIV-1 infection. 

Levesque, Marc C; Moody, M Anthony; Hwang, Kwan-Ki; Marshall, Dawn J; Whitesides, John F; Amos, Joshua D; Gurley, Thaddeus C; ... (25 authors) (PLoS Med, 2009-07-07)
BACKGROUND: The antibody response to HIV-1 does not appear in the plasma until approximately 2-5 weeks after transmission, and neutralizing antibodies to autologous HIV-1 generally do not become detectable until 12 weeks ...
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Polymorphisms of TGFB1 and VEGF genes and survival of patients with gastric cancer. 

Guan, Xiaoxiang; Zhao, Hui; Niu, Jiangong; Tan, Dongfeng; Ajani, Jaffer A; Wei, Qingyi (Journal of experimental & clinical cancer research : CR, 2009-06-30)
Some TGFB1 and VEGF polymorphisms are believed to be functional. Given that these genes are involved in tumor growth and progression including angiogenesis, dissemination, and invasiveness, we hypothesized that ...
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The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer. 

Guan, Xiaoxiang; Zhao, Hui; Niu, Jiangong; Tang, Dongfeng; Ajani, Jaffer A; Wei, Qingyi (BMC gastroenterology, 2009-10-16)
Both TGF-beta1 and VEGF play a critic role in the multiple-step process of tumorgenesis of gastric cancer. Single nucleotide polymorphisms (SNPs) of the TGFB1 and VEGF genes have been associated with risk and progression ...
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Serial dilution curve: a new method for analysis of reverse phase protein array data. 

Zhang, Li; Wei, Qingyi; Mao, Li; Liu, Wenbin; Mills, Gordon B; Coombes, Kevin (Bioinformatics (Oxford, England), 2009-03)
Reverse phase protein arrays (RPPAs) are a powerful high-throughput tool for measuring protein concentrations in a large number of samples. In RPPA technology, the original samples are often diluted successively multiple ...
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Metronomic chemotherapy with daily, oral etoposide plus bevacizumab for recurrent malignant glioma: a phase II study. 

Reardon, DA; Desjardins, A; Vredenburgh, JJ; Gururangan, S; Sampson, JH; Sathornsumetee, S; McLendon, RE; ... (13 authors) (Br J Cancer, 2009-12-15)
BACKGROUND: We evaluated bevacizumab with metronomic etoposide among recurrent malignant glioma patients in a phase 2, open-label trial. METHODS: A total of 59 patients, including 27 with glioblastoma (GBM) and 32 with grade ...
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Evaluation and recommendations on good clinical laboratory practice guidelines for phase I-III clinical trials. 

Sarzotti-Kelsoe, Marcella; Cox, Josephine; Cleland, Naana; Denny, Thomas; Hural, John; Needham, Leila; Ozaki, Daniel; ... (12 authors) (PLoS Med, 2009-05-26)
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MYC activity mitigates response to rapamycin in prostate cancer through eukaryotic initiation factor 4E-binding protein 1-mediated inhibition of autophagy. 

Balakumaran, Bala S; Porrello, Alessandro; Hsu, David S; Glover, Wayne; Foye, Adam; Leung, Janet Y; Sullivan, Beth A; ... (10 authors) (Cancer Res, 2009-10-01)
Loss of PTEN and activation of phosphoinositide 3-kinase are commonly observed in advanced prostate cancer. Inhibition of mammalian target of rapamycin (mTOR), a downstream target of phosphoinositide 3-kinase signaling, ...
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Common genetic variation and the control of HIV-1 in humans. 

Fellay, Jacques; Ge, Dongliang; Shianna, Kevin V; Colombo, Sara; Ledergerber, Bruno; Cirulli, Elizabeth T; Urban, Thomas J; ... (38 authors) (PLoS Genet, 2009-12)
To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants ...
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AuthorWei, Qingyi (3)Ajani, Jaffer A (2)Guan, Xiaoxiang (2)Haynes, Barton F (2)Niu, Jiangong (2)Zhao, Hui (2)Allgood, Sallie (1)Amos, Joshua D (1)Anderson, R (1)Antonarakis, Stylianos E (1)... View MoreDate Issued
2009 (14)
TypeJournal article (14)SubjectHumans (12)Male (8)Female (6)Middle Aged (6)Adult (5)Aged (4)Genotype (4)Adolescent (3)Alleles (3)Animals (3)... View MoreAffiliation of Duke Author(s)
Basic Science Departments (14)
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Duke (14)
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Medicine (14)
School of Medicine (14)
Duke Cancer Institute (10)Molecular Genetics and Microbiology (7)Duke Clinical Research Institute (6)Medicine, Medical Oncology (5)... View More
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