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Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients.
After stimulation, dendritic cells (DCs) mature and migrate to draining lymph nodes to induce immune responses. As such, autologous DCs generated ex vivo have been pulsed with tumour antigens and injected back into patients ...
RNA-Based Vaccines in Cancer Immunotherapy.
(J Immunol Res, 2015)
RNA vaccines traditionally consist of messenger RNA synthesized by in vitro transcription using a bacteriophage RNA polymerase and template DNA that encodes the antigen(s) of interest. Once administered and internalized ...