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Rationale and design of the Exercise Intensity Trial (EXCITE): A randomized trial comparing the effects of moderate versus moderate to high-intensity aerobic training in women with operable breast cancer.
(BMC Cancer, 2010-10-06)
BACKGROUND: The Exercise Intensity Trial (EXcITe) is a randomized trial to compare
the efficacy of supervised moderate-intensity aerobic training to moderate to high-intensity
aerobic training, relative to attention control, ...
An item response theory analysis of DSM-IV criteria for hallucinogen abuse and dependence in adolescents.
(Addictive behaviors, 2010-03)
AIM:This study applied both item response theory (IRT) and multiple indicators-multiple
causes (MIMIC) methods to evaluate item-level psychometric properties of diagnostic
questions for hallucinogen use disorders (HUDs), ...
Variation in the type and frequency of postoperative invasive Staphylococcus aureus infections according to type of surgical procedure.
(Infect Control Hosp Epidemiol, 2010-07)
OBJECTIVE: To determine the epidemiological characteristics of postoperative invasive
Staphylococcus aureus infection following 4 types of major surgical procedures.design.
Retrospective cohort study. SETTING: Eleven hospitals ...
Genotypes and haplotypes of the VEGF gene and survival in locally advanced non-small cell lung cancer patients treated with chemoradiotherapy.
(BMC cancer, 2010-08-16)
Vascular endothelial growth factor (VEGF) is a major mediator of angiogenesis involving
in carcinogenesis, including lung cancer. We hypothesized that VEGF polymorphisms
may affect survival outcomes among locally advanced ...
Can metaphors and analogies improve communication with seriously ill patients?
(J Palliat Med, 2010-03)
OBJECTIVE: It is not known how often physicians use metaphors and analogies, or whether
they improve patients' perceptions of their physicians' ability to communicate effectively.
Therefore, the objective of this study was ...
Immunization with cocktail of HIV-derived peptides in montanide ISA-51 is immunogenic, but causes sterile abscesses and unacceptable reactogenicity.
(PLoS One, 2010-08-10)
BACKGROUND: A peptide vaccine was produced containing B and T cell epitopes from the
V3 and C4 Envelope domains of 4 subtype B HIV-1 isolates (MN, RF, CanO, & Ev91). The
peptide mixture was formulated as an emulsion in incomplete ...
Impact of gene variants on sex-specific regulation of human Scavenger receptor class B type 1 (SR-BI) expression in liver and association with lipid levels in a population-based study.
(BMC Med Genet, 2010-01-19)
BACKGROUND: Several studies have noted that genetic variants of SCARB1, a lipoprotein
receptor involved in reverse cholesterol transport, are associated with serum lipid
levels in a sex-dependent fashion. However, the mechanism ...
An alphavirus vector overcomes the presence of neutralizing antibodies and elevated numbers of Tregs to induce immune responses in humans with advanced cancer.
(J Clin Invest, 2010-09)
Therapeutic anticancer vaccines are designed to boost patients' immune responses to
tumors. One approach is to use a viral vector to deliver antigen to in situ DCs, which
then activate tumor-specific T cell and antibody ...
Variation in use of surveillance colonoscopy among colorectal cancer survivors in the United States.
(BMC Health Serv Res, 2010-09-01)
BACKGROUND: Clinical practice guidelines recommend colonoscopies at regular intervals
for colorectal cancer (CRC) survivors. Using data from a large, multi-regional, population-based
cohort, we describe the rate of surveillance ...
Predicting virologic failure among HIV-1-infected children receiving antiretroviral therapy in Tanzania: a cross-sectional study.
(J Acquir Immune Defic Syndr, 2010-08)
BACKGROUND: Many HIV care and treatment programs in resource-limited settings rely
on clinical and immunologic monitoring of antiretroviral therapy (ART), but accuracy
of this strategy to detect virologic failure (VF) among ...