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Ghrelin suppresses glucose-stimulated insulin secretion and deteriorates glucose tolerance in healthy humans.

Bidlingmaier, M; Cummings, DE; D'Alessio, David A; Davis, HW; Kahn, SE; Prigeon, RL; Tong, Jenny; ... (8 authors) (Diabetes, 2010-09)

OBJECTIVE: The orexigenic gut hormone ghrelin and its receptor are present in pancreatic islets. Although ghrelin reduces insulin secretion in rodents, its effect on insulin secretion in humans has not been established. ...

Integrated analysis of CANVAS 1 and 2: phase 3, multicenter, randomized, double-blind studies to evaluate the safety and efficacy of ceftaroline versus vancomycin plus aztreonam in complicated skin and skin-structure infection.

Corey, GR; Wilcox, M; Talbot, GH; Friedland, HD; Baculik, T; Witherell, GW; Critchley, I; ... (9 authors) (Clin Infect Dis, 2010-09-15)

BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) is a common cause of complicated skin and skin-structure infection (cSSSI). Increasing antimicrobial resistance in cSSSI has led to a need for new safe and effective ...

Predicting virologic failure among HIV-1-infected children receiving antiretroviral therapy in Tanzania: a cross-sectional study.

Bartlett, John A; Crump, John Andrew; Cunningham, Coleen; Emmett, Susan D; Kinabo, GD; Mmbaga, BT; Reddy, Elizabeth A; ... (9 authors) (J Acquir Immune Defic Syndr, 2010-08)

BACKGROUND: Many HIV care and treatment programs in resource-limited settings rely on clinical and immunologic monitoring of antiretroviral therapy (ART), but accuracy of this strategy to detect virologic failure (VF) among ...

Variation in the type and frequency of postoperative invasive Staphylococcus aureus infections according to type of surgical procedure.

Anderson, DJ; Arduino, JM; Choi, YI; Fowler, Vance Garrison Jr; Friedman, JY; Grussemeyer, CA; Hardy, C; ... (11 authors) (Infect Control Hosp Epidemiol, 2010-07)

OBJECTIVE: To determine the epidemiological characteristics of postoperative invasive Staphylococcus aureus infection following 4 types of major surgical procedures.design. Retrospective cohort study. SETTING: Eleven hospitals ...

Young caregivers in the end-of-life setting: a population-based profile of an emerging group.

Abernethy, Amy Pickar; Burns, CM; Currow, D; LeBlanc, Thomas William (J Palliat Med, 2010-10)

PURPOSE: Little is known about young caregivers of people with advanced life-limiting illness. Better understanding of the needs and characteristics of these young caregivers can inform development of palliative care and ...

Immunization with cocktail of HIV-derived peptides in montanide ISA-51 is immunogenic, but causes sterile abscesses and unacceptable reactogenicity.

AIDS Vaccine Evaluation Group; Berger, D; Duerr, A; Eldridge, J; Fast, P; Ferarri, G; Ginsberg, R; ... (17 authors) (PLoS One, 2010-08-10)

BACKGROUND: A peptide vaccine was produced containing B and T cell epitopes from the V3 and C4 Envelope domains of 4 subtype B HIV-1 isolates (MN, RF, CanO, & Ev91). The peptide mixture was formulated as an emulsion in incomplete ...