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Differential developmental trajectories of magnetic susceptibility in human brain gray and white matter over the lifespan.
(Hum Brain Mapp, 2014-06)
As indicated by several recent studies, magnetic susceptibility of the brain is influenced
mainly by myelin in the white matter and by iron deposits in the deep nuclei. Myelination
and iron deposition in the brain evolve ...
Interstitial engraftment of adipose-derived stem cells into an acellular dermal matrix results in improved inward angiogenesis and tissue incorporation.
(J Biomed Mater Res A, 2013-10)
Acellular dermal matrices (ADM) are commonly used in reconstructive procedures and
rely on host cell invasion to become incorporated into host tissues. We investigated
different approaches to adipose-derived stem cells (ASCs) ...
Two genes on A/J chromosome 18 are associated with susceptibility to Staphylococcus aureus infection by combined microarray and QTL analyses.
(PLoS Pathog, 2010-09-02)
Although it has recently been shown that A/J mice are highly susceptible to Staphylococcus
aureus sepsis as compared to C57BL/6J, the specific genes responsible for this differential
phenotype are unknown. Using chromosome ...
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress.
(Science (New York, N.Y.), 2005-02)
Most protein phosphatases have little intrinsic substrate specificity, making selective
pharmacological inhibition of specific dephosphorylation reactions a challenging problem.
In a screen for small molecules that protect ...
MRP3: a molecular target for human glioblastoma multiforme immunotherapy.
(BMC Cancer, 2010-09-01)
BACKGROUND: Glioblastoma multiforme (GBM) is refractory to conventional therapies.
To overcome the problem of heterogeneity, more brain tumor markers are required for
prognosis and targeted therapy. We have identified and ...
Institutional review boards' use and understanding of certificates of confidentiality.
(PloS one, 2012-01)
Certificates of Confidentiality, issued by agencies of the U.S. government, are regarded
as an important tool for meeting ethical and legal obligations to safeguard research
participants' privacy and confidentiality. By ...
Intracoronary adenovirus-mediated delivery and overexpression of the beta(2)-adrenergic receptor in the heart : prospects for molecular ventricular assistance.
(Circulation, 2000-02-01)
BACKGROUND: Genetic modulation of ventricular function may offer a novel therapeutic
strategy for patients with congestive heart failure. Myocardial overexpression of
beta(2)-adrenergic receptors (beta(2)ARs) has been shown ...
Gene expression signatures of radiation response are specific, durable and accurate in mice and humans.
(PLoS One, 2008-04-02)
BACKGROUND: Previous work has demonstrated the potential for peripheral blood (PB)
gene expression profiling for the detection of disease or environmental exposures.
METHODS AND FINDINGS: We have sought to determine the ...
Gastroesophageal reflux symptoms are not sufficient to guide esophageal function testing in lung transplant candidates.
(Diseases of the esophagus : official journal of the International Society for Diseases
of the Esophagus, 2018-05)
Gastroesophageal reflux disease and esophageal dysmotility are prevalent in patients
with advanced lung disease and are associated with graft dysfunction following lung
transplantation. As a result, many transplant centers ...
Potential Cost-effectiveness of Early Identification of Hospital-acquired Infection in Critically Ill Patients.
(Ann Am Thorac Soc, 2016-03)
RATIONALE: Limitations in methods for the rapid diagnosis of hospital-acquired infections
often delay initiation of effective antimicrobial therapy. New diagnostic approaches
offer potential clinical and cost-related improvements ...