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Refusal in testicular cancer patients: implications for surveillance.
(Br J Cancer, 1992-05)
Overexpression of the cardiac beta(2)-adrenergic receptor and expression of a beta-adrenergic receptor kinase-1 (betaARK1) inhibitor both increase myocardial contractility but have differential effects on susceptibility to ischemic injury.
(Circ Res, 1999-11-26)
Cardiac beta(2)-adrenergic receptor (beta(2)AR) overexpression is a potential contractile
therapy for heart failure. Cardiac contractility was elevated in mice overexpressing
beta(2)ARs (TG4s) with no adverse effects under ...
Enhancement of cardiac function after adenoviral-mediated in vivo intracoronary beta2-adrenergic receptor gene delivery.
(J Clin Invest, 1999-07)
Exogenous gene delivery to alter the function of the heart is a potential novel therapeutic
strategy for treatment of cardiovascular diseases such as heart failure (HF). Before
gene therapy approaches to alter cardiac function ...
Localisation of [131I]MIBG in nude mice bearing SK-N-SH human neuroblastoma xenografts: effect of specific activity.
(Br J Cancer, 1996-05)
The biodistribution of no-carrier-added (n.c.a.) meta-[131I]iodobenzylguanidine ([131I]MIBG)
and that prepared by the standard isotopic exchange method were compared in athymic
mice bearing SK-N-SH human neuroblastoma xenografts. ...
Characterization of the murine BEK fibroblast growth factor (FGF) receptor: activation by three members of the FGF family and requirement for heparin.
(Proc Natl Acad Sci U S A, 1992-04-15)
The bek gene encodes a member of the high-affinity fibroblast growth factor receptor
family. The BEK/FGFR-2 receptor is a membrane-spanning tyrosine kinase with the typical
features of FGF receptors. We have cloned a murine ...
Restoration of beta-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer.
(Proc Natl Acad Sci U S A, 1997-10-28)
Cardiovascular gene therapy is a novel approach to the treatment of diseases such
as congestive heart failure (CHF). Gene transfer to the heart would allow for the
replacement of defective or missing cellular proteins that ...
3-[211At]astato-4-fluorobenzylguanidine: a potential therapeutic agent with prolonged retention by neuroblastoma cells.
(Br J Cancer, 1997)
An analogue of meta-iodobenzylguanidine (MIBG) in which an aromatic hydrogen was replaced
with fluorine has been found to possess many properties similar to those of the parent
compound. Moreover, 4-fluoro-3-iodobenzylguanidine ...
Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes.
(Circ Res, 1999-01-08)
-Transgenic mouse models have been developed to manipulate beta-adrenergic receptor
(betaAR) signal transduction. Although several of these models have altered betaAR
subtypes, the specific functional sequelae of betaAR ...
Potentiation of beta-adrenergic signaling by adenoviral-mediated gene transfer in adult rabbit ventricular myocytes.
(J Clin Invest, 1997-01-15)
Our laboratory has been testing the hypothesis that genetic modulation of the beta-adrenergic
signaling cascade can enhance cardiac function. We have previously shown that transgenic
mice with cardiac overexpression of either ...
beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein.
(Proc Natl Acad Sci U S A, 1998-11-24)
G protein-coupled receptor activation leads to the membrane recruitment and activation
of G protein-coupled receptor kinases, which phosphorylate receptors and lead to their
inactivation. We have identified a novel ...