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Associations of PI3KR1 and mTOR polymorphisms with esophageal squamous cell carcinoma risk and gene-environment interactions in Eastern Chinese populations.

Wei, Qingyi; Zhu, Jinhong; Wang, Mengyun; Zhu, Meiling; He, Jin; Wang, Jiu-Cun; Jin, Li; ... (9 authors) (Scientific reports, 2015-01)

Single nucleotide polymorphisms (SNPs) in the PI3K/PTEN/AKT/mTOR signaling pathway may contribute to carcinogenesis. We genotyped five potentially functional PIK3R1 and mTOR SNPs in 1116 esophageal squamous cell cancer (ESCC) ...

Potentially functional polymorphisms in the CASP7 gene contribute to gastric adenocarcinoma susceptibility in an eastern Chinese population.

Wei, Qingyi; Wang, Meng-Yun; Zhu, Mei-Ling; He, Jing; Shi, Ting-Yan; Li, Qiao-Xin; Wang, Ya-Nong; ... (14 authors) (PloS one, 2013-01)

BACKGROUND: Caspase 7 (CASP7) is an important regulator and executioner in the apoptosis pathway and plays a crucial role in cancer development and progression. However, few studies have evaluated associations between functional ...

Associations of potentially functional variants in IL-6, JAKs and STAT3 with gastric cancer risk in an eastern Chinese population.

Wei, Qingyi; Zhou, Fei; Cheng, Lei; Qiu, Li-Xin; Wang, Meng-Yun; Li, Jin; Sun, Meng-Hong; ... (11 authors) (Oncotarget, 2016-05)

The interleukin-6 (IL-6)/JAK/STAT3 signaling pathway plays a central role in inflammation-mediated cancers, including gastric cancer (GCa). We evaluated associations between 10 potentially functional single nucleotide ...

A Functional Polymorphism (rs2494752) in the AKT1 Promoter Region and Gastric Adenocarcinoma Risk in an Eastern Chinese Population.

Wei, Qingyi; Wang, Meng-Yun; He, Jing; Zhu, Mei-Ling; Teng, Xiao-Yan; Li, Qiao-Xin; Sun, Meng-Hong; ... (12 authors) (Scientific reports, 2016-01-28)

AKT is an important signal transduction protein that plays a crucial role in cancer development. Therefore, we evaluated associations between single nucleotide polymorphisms (SNPs) in the AKT promoter region and gastric ...

Pri-miR-124 rs531564 and pri-miR-34b/c rs4938723 polymorphisms are associated with decreased risk of esophageal squamous cell carcinoma in Chinese populations.

Wei, Qingyi; Zhang, Junjie; Huang, Xuewen; Xiao, Juanjuan; Yang, Yajun; Zhou, Yinghui; Wang, Xiaofeng; ... (18 authors) (PloS one, 2014-01)

MicroRNAs are a new class of small non-protein-coding RNAs that sometimes function as tumor suppressors or oncogenes. Aberrant expression and structural alteration of microRNAs have been reported to be involved in tumorigenesis ...

Tumor necrosis factor-α induced protein 8 polymorphism and risk of non-Hodgkin's lymphoma in a Chinese population: a case-control study.

Wei, Qingyi; Zhang, Yan; Wang, Meng-Yun; He, Jing; Wang, Jiu-Cun; Yang, Ya-Jun; Jin, Li; ... (13 authors) (PloS one, 2012-01)

BACKGROUND: Non-Hodgkin's lymphoma (NHL) has been reported to be associated with autoimmune and pro-inflammatory response, and genetic polymorphisms of candidate genes involved in autoimmune and pro-inflammatory response ...