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HIV-1 Envelope Glycoproteins from Diverse Clades Differentiate Antibody Responses and Durability among Vaccinees.
(Journal of virology, 2018-04)
Induction of broadly cross-reactive antiviral humoral responses with the capacity
to target globally diverse circulating strains is a key goal for HIV-1 immunogen design.
A major gap in the field is the identification of ...
Metabolic regulation of T lymphocytes.
(Annu Rev Immunol, 2013)
T cell activation leads to dramatic shifts in cell metabolism to protect against pathogens
and to orchestrate the action of other immune cells. Quiescent T cells require predominantly
ATP-generating processes, whereas ...
MiR-215 Is Induced Post-transcriptionally via HIF-Drosha Complex and Mediates Glioma-Initiating Cell Adaptation to Hypoxia by Targeting KDM1B.
(Cancer Cell, 2016-01-11)
The hypoxic tumor microenvironment serves as a niche for maintaining the glioma-initiating
cells (GICs) that are critical for glioblastoma (GBM) occurrence and recurrence. Here,
we report that hypoxia-induced miR-215 is ...
Protein tyrosine phosphatase-σ regulates hematopoietic stem cell-repopulating capacity.
(J Clin Invest, 2015-01)
Hematopoietic stem cell (HSC) function is regulated by activation of receptor tyrosine
kinases (RTKs). Receptor protein tyrosine phosphatases (PTPs) counterbalance RTK signaling;
however, the functions of receptor PTPs in ...
Lack of B cell dysfunction is associated with functional, gp120-dominant antibody responses in breast milk of simian immunodeficiency virus-infected African green monkeys.
(J Virol, 2013-10)
The design of an effective vaccine to reduce the incidence of mother-to-child transmission
(MTCT) of human immunodeficiency virus (HIV) via breastfeeding will require identification
of protective immune responses that block ...
Human Non-neutralizing HIV-1 Envelope Monoclonal Antibodies Limit the Number of Founder Viruses during SHIV Mucosal Infection in Rhesus Macaques.
(PLoS Pathog, 2015-08)
HIV-1 mucosal transmission begins with virus or virus-infected cells moving through
mucus across mucosal epithelium to infect CD4+ T cells. Although broadly neutralizing
antibodies (bnAbs) are the type of HIV-1 antibodies ...
Type III TGF-β receptor downregulation generates an immunotolerant tumor microenvironment.
(J Clin Invest, 2013-09)
Cancers subvert the host immune system to facilitate disease progression. These evolved
immunosuppressive mechanisms are also implicated in circumventing immunotherapeutic
strategies. Emerging data indicate that ...
Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV.
(Nature, 2014-01-23)
A major challenge for the development of a highly effective AIDS vaccine is the identification
of mechanisms of protective immunity. To address this question, we used a nonhuman
primate challenge model with simian ...
CPAG: software for leveraging pleiotropy in GWAS to reveal similarity between human traits links plasma fatty acids and intestinal inflammation.
(Genome Biol, 2015-09-15)
Meta-analyses of genome-wide association studies (GWAS) have demonstrated that the
same genetic variants can be associated with multiple diseases and other complex traits.
We present software called CPAG (Cross-Phenotype ...
Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies.
(J Exp Med, 2013-02-11)
Many human monoclonal antibodies that neutralize multiple clades of HIV-1 are polyreactive
and bind avidly to mammalian autoantigens. Indeed, the generation of neutralizing
antibodies to the 2F5 and 4E10 epitopes of HIV-1 ...