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Association between novel PLCE1 variants identified in published esophageal cancer genome-wide association studies and risk of squamous cell carcinoma of the head and neck.
(BMC cancer, 2011-06-20)
Phospholipase C epsilon 1 (PLCE1) (an effector of Ras) belonging to the phospholipase
family plays crucial roles in carcinogenesis and progression of several cancers, including
squamous cell carcinoma of the head and neck ...
Polymorphisms in the AKT1 and AKT2 genes and oesophageal squamous cell carcinoma risk in an Eastern Chinese population.
(Journal of cellular and molecular medicine, 2016-04)
Ethnic Han Chinese are at high risk of developing oesophageal squamous cell carcinoma
(ESCC). Aberrant activation of the AKT signalling pathway is involved in many cancers,
including ESCC. Some single nucleotide polymorphisms ...
On the interplay of telomeres, nevi and the risk of melanoma.
(PloS one, 2012-01)
The relationship between telomeres, nevi and melanoma is complex. Shorter telomeres
have been found to be associated with many cancers and with number of nevi, a known
risk factor for melanoma. However, shorter telomeres ...
A genetic variant in the APE1/Ref-1 gene promoter -141T/G may modulate risk of glioblastoma in a Chinese Han population.
(BMC cancer, 2011-01)
BACKGROUND: The human apurinic/apyrimidinic endonuclease 1/Redox effector factor-1
(APE1/Ref-1) is implicated in tumor development and progression. Recently, the APE1/Ref-1
promoter -141T/G variant (rs1760944) has been reported ...
Associations of potentially functional variants in IL-6, JAKs and STAT3 with gastric cancer risk in an eastern Chinese population.
(Oncotarget, 2016-05)
The interleukin-6 (IL-6)/JAK/STAT3 signaling pathway plays a central role in inflammation-mediated
cancers, including gastric cancer (GCa). We evaluated associations between 10 potentially
functional single nucleotide ...
Polymorphisms in nucleotide excision repair genes and risk of primary prostate cancer in Chinese Han populations.
(Oncotarget, 2017-04)
Genetic variants of nucleotide excision repair (NER) genes have been extensively investigated
for their roles in the development of prostate cancer (PCa); however, the published
results have been inconsistent. In a hospital-based ...
Polymorphisms in the ERCC5 gene and risk of esophageal squamous cell carcinoma (ESCC) in Eastern Chinese populations.
(PloS one, 2012-01)
BACKGROUND: Excision repair cross complementing group 5 (ERCC5 or XPG) plays an important
role in regulating DNA excision repair; its functional single nucleotide polymorphisms
(SNPs) may alter DNA repair capacity and thus ...
A Functional Polymorphism (rs2494752) in the AKT1 Promoter Region and Gastric Adenocarcinoma Risk in an Eastern Chinese Population.
(Scientific reports, 2016-01-28)
AKT is an important signal transduction protein that plays a crucial role in cancer
development. Therefore, we evaluated associations between single nucleotide polymorphisms
(SNPs) in the AKT promoter region and gastric ...
Pri-miR-124 rs531564 and pri-miR-34b/c rs4938723 polymorphisms are associated with decreased risk of esophageal squamous cell carcinoma in Chinese populations.
(PloS one, 2014-01)
MicroRNAs are a new class of small non-protein-coding RNAs that sometimes function
as tumor suppressors or oncogenes. Aberrant expression and structural alteration of
microRNAs have been reported to be involved in tumorigenesis ...
PSCA polymorphisms and gastric cancer susceptibility in an eastern Chinese population.
(Oncotarget, 2016-02)
The prostate stem cell antigen (PSCA) gene, which encodes a prostate-specific antigen
(PSA), was identified as a gene involved in cell adhesion and proliferation. The associations
between the PSCA rs2294008 and rs2976392 ...