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Genotypes and haplotypes of the VEGF gene and survival in locally advanced non-small cell lung cancer patients treated with chemoradiotherapy.
(BMC cancer, 2010-08-16)
Vascular endothelial growth factor (VEGF) is a major mediator of angiogenesis involving
in carcinogenesis, including lung cancer. We hypothesized that VEGF polymorphisms
may affect survival outcomes among locally advanced ...
Effects of FOXO genotypes on longevity: a biodemographic analysis.
(J Gerontol A Biol Sci Med Sci, 2010-12)
Based on data from 760 centenarians and 1060 middle-age controls (all Han Chinese),
this article contributes biodemographic insights and syntheses concerning the magnitude
of effects of the FOXO genotypes on longevity. We ...
MRP3: a molecular target for human glioblastoma multiforme immunotherapy.
(BMC Cancer, 2010-09-01)
BACKGROUND: Glioblastoma multiforme (GBM) is refractory to conventional therapies.
To overcome the problem of heterogeneity, more brain tumor markers are required for
prognosis and targeted therapy. We have identified and ...
Viral factors induce Hedgehog pathway activation in humans with viral hepatitis, cirrhosis, and hepatocellular carcinoma.
(Lab Invest, 2010-12)
Hedgehog (Hh) pathway activation promotes many processes that occur during fibrogenic
liver repair. Whether the Hh pathway modulates the outcomes of virally mediated liver
injury has never been examined. Gene-profiling studies ...
First qualification study of serum biomarkers as indicators of total body burden of osteoarthritis.
(PLoS One, 2010-03-17)
BACKGROUND: Osteoarthritis (OA) is a debilitating chronic multijoint disease of global
proportions. OA presence and severity is usually documented by x-ray imaging but whole
body imaging is impractical due to radiation exposure, ...
IDH1(R132) mutation identified in one human melanoma metastasis, but not correlated with metastases to the brain.
(Biochemical and biophysical research communications, 2010-07-13)
Isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) are enzymes
which convert isocitrate to alpha-ketoglutarate while reducing nicotinamide adenine
dinucleotide phosphate (NADP+to NADPH). IDH1/2 were ...
Can metaphors and analogies improve communication with seriously ill patients?
(J Palliat Med, 2010-03)
OBJECTIVE: It is not known how often physicians use metaphors and analogies, or whether
they improve patients' perceptions of their physicians' ability to communicate effectively.
Therefore, the objective of this study was ...
Variation in the type and frequency of postoperative invasive Staphylococcus aureus infections according to type of surgical procedure.
(Infect Control Hosp Epidemiol, 2010-07)
OBJECTIVE: To determine the epidemiological characteristics of postoperative invasive
Staphylococcus aureus infection following 4 types of major surgical procedures.design.
Retrospective cohort study. SETTING: Eleven hospitals ...
MRP3: a molecular target for human glioblastoma multiforme immunotherapy.
(BMC Cancer, 2010-09-01)
BACKGROUND: Glioblastoma multiforme (GBM) is refractory to conventional therapies.
To overcome the problem of heterogeneity, more brain tumor markers are required for
prognosis and targeted therapy. We have identified and ...
Pairing QuantiFERON gold in-tube with opt-out HIV testing in a tuberculosis contact investigation in the Southeastern United States.
(AIDS Patient Care STDS, 2010-09)
Knowing one's HIV status is particularly important in the setting of recent tuberculosis
(TB) exposure. Blood tests for assessment of tuberculosis infection, such as the QuantiFERON
Gold in-tube test (QFT; Cellestis Limited, ...