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MRP3: a molecular target for human glioblastoma multiforme immunotherapy.
(BMC Cancer, 2010-09-01)
BACKGROUND: Glioblastoma multiforme (GBM) is refractory to conventional therapies.
To overcome the problem of heterogeneity, more brain tumor markers are required for
prognosis and targeted therapy. We have identified and ...
Variation in the type and frequency of postoperative invasive Staphylococcus aureus infections according to type of surgical procedure.
(Infect Control Hosp Epidemiol, 2010-07)
OBJECTIVE: To determine the epidemiological characteristics of postoperative invasive
Staphylococcus aureus infection following 4 types of major surgical procedures.design.
Retrospective cohort study. SETTING: Eleven hospitals ...
MRP3: a molecular target for human glioblastoma multiforme immunotherapy.
(BMC Cancer, 2010-09-01)
BACKGROUND: Glioblastoma multiforme (GBM) is refractory to conventional therapies.
To overcome the problem of heterogeneity, more brain tumor markers are required for
prognosis and targeted therapy. We have identified and ...
Genotypes and haplotypes of the VEGF gene and survival in locally advanced non-small cell lung cancer patients treated with chemoradiotherapy.
(BMC cancer, 2010-08-16)
Vascular endothelial growth factor (VEGF) is a major mediator of angiogenesis involving
in carcinogenesis, including lung cancer. We hypothesized that VEGF polymorphisms
may affect survival outcomes among locally advanced ...
Pairing QuantiFERON gold in-tube with opt-out HIV testing in a tuberculosis contact investigation in the Southeastern United States.
(AIDS Patient Care STDS, 2010-09)
Knowing one's HIV status is particularly important in the setting of recent tuberculosis
(TB) exposure. Blood tests for assessment of tuberculosis infection, such as the QuantiFERON
Gold in-tube test (QFT; Cellestis Limited, ...
Can metaphors and analogies improve communication with seriously ill patients?
(J Palliat Med, 2010-03)
OBJECTIVE: It is not known how often physicians use metaphors and analogies, or whether
they improve patients' perceptions of their physicians' ability to communicate effectively.
Therefore, the objective of this study was ...
Immunization with cocktail of HIV-derived peptides in montanide ISA-51 is immunogenic, but causes sterile abscesses and unacceptable reactogenicity.
(PLoS One, 2010-08-10)
BACKGROUND: A peptide vaccine was produced containing B and T cell epitopes from the
V3 and C4 Envelope domains of 4 subtype B HIV-1 isolates (MN, RF, CanO, & Ev91). The
peptide mixture was formulated as an emulsion in incomplete ...
An alphavirus vector overcomes the presence of neutralizing antibodies and elevated numbers of Tregs to induce immune responses in humans with advanced cancer.
(J Clin Invest, 2010-09)
Therapeutic anticancer vaccines are designed to boost patients' immune responses to
tumors. One approach is to use a viral vector to deliver antigen to in situ DCs, which
then activate tumor-specific T cell and antibody ...
Genome-wide scan of copy number variation in late-onset Alzheimer's disease.
(J Alzheimers Dis, 2010)
Alzheimer's disease is a complex and progressive neurodegenerative disease leading
to loss of memory, cognitive impairment, and ultimately death. To date, six large-scale
genome-wide association studies have been conducted ...
First qualification study of serum biomarkers as indicators of total body burden of osteoarthritis.
(PLoS One, 2010-03-17)
BACKGROUND: Osteoarthritis (OA) is a debilitating chronic multijoint disease of global
proportions. OA presence and severity is usually documented by x-ray imaging but whole
body imaging is impractical due to radiation exposure, ...