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Correlation between base-excision repair gene polymorphisms and levels of in-vitro BPDE-induced DNA adducts in cultured peripheral blood lymphocytes.
(PloS one, 2012-01)
In vitro benzo[a]pyrene diol epoxide (BPDE)-induced DNA adducts in cultured peripheral
lymphocytes have been shown to be a phenotypic biomarker of individual's DNA repair
phenotype that is associated with cancer risk. In ...
Association of combined p73 and p53 genetic variants with tumor HPV16-positive oropharyngeal cancer.
(PloS one, 2012-01)
p53 and p73 interact with human papillomavirus (HPV) E6 and E7 oncoproteins. The interplay
between p53 and p73 and HPV16 may lead to deregulation of cell cycle and apoptosis,
through which inflammation/immune responses control ...
Genetic variants of p27 and p21 as predictors for risk of second primary malignancy in patients with index squamous cell carcinoma of head and neck.
(Molecular cancer, 2012-03-26)
Cell cycle deregulation is common in human cancer, and alterations of p27 and p21,
two critical cell cycle regulators, have been implicated in the development of many
human malignancies. Therefore, we hypothesize that p27 ...
Association between single nucleotide polymorphisms in ERCC4 and risk of squamous cell carcinoma of the head and neck.
(PloS one, 2012-01)
Excision repair cross-complementation group 4 gene (ERCC4/XPF) plays an important
role in nucleotide excision repair and participates in removal of DNA interstrand
cross-links and DNA double-strand breaks. Single nucleotide ...
Genetic variants of NOXA and MCL1 modify the risk of HPV16-associated squamous cell carcinoma of the head and neck.
(BMC cancer, 2012-05)
The cooperation between phorbol 12-myristate 13-acetate induced protein 1 (NOXA) and
myeloid cell leukemia 1 (MCL1) is critical in the intrinsic apoptotic pathway. Human
papillomavirus 16 (HPV16), by inducing p53 and pRb-E2F ...
A pilot study of IL-2Rα blockade during lymphopenia depletes regulatory T-cells and correlates with enhanced immunity in patients with glioblastoma.
(PLoS One, 2012)
BACKGROUND: Preclinical studies in mice have demonstrated that the prophylactic depletion
of immunosuppressive regulatory T-cells (T(Regs)) through targeting the high affinity
interleukin-2 (IL-2) receptor (IL-2Rα/CD25) ...
Bacteremic disseminated tuberculosis in sub-saharan Africa: a prospective cohort study.
(Clin Infect Dis, 2012-07)
BACKGROUND: Disseminated tuberculosis is a major health problem in countries where
generalized human immunodeficiency virus (HIV) infection epidemics coincide with high
tuberculosis incidence rates; data are limited on patient ...
Evaluating the number of stages in development of squamous cell and adenocarcinomas across cancer sites using human population-based cancer modeling.
(PLoS One, 2012)
BACKGROUND: Adenocarcinomas (ACs) and squamous cell carcinomas (SCCs) differ by clinical
and molecular characteristics. We evaluated the characteristics of carcinogenesis
by modeling the age patterns of incidence rates of ...
Geographic information system-based screening for TB, HIV, and syphilis (GIS-THIS): a cross-sectional study.
(PLoS One, 2012)
OBJECTIVE: To determine the feasibility and case detection rate of a geographic information
systems (GIS)-based integrated community screening strategy for tuberculosis, syphilis,
and human immunodeficiency virus (HIV). ...
Caloric restriction alters the metabolic response to a mixed-meal: results from a randomized, controlled trial.
(PLoS One, 2012)
OBJECTIVES: To determine if caloric restriction (CR) would cause changes in plasma
metabolic intermediates in response to a mixed meal, suggestive of changes in the
capacity to adapt fuel oxidation to fuel availability or ...