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Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds.

Choy, EW; Field, ME; Lefkowitz, Robert J; Luttrell, LM; Miller, WE; Pierce, KL; Roudabush, FL (Proc Natl Acad Sci U S A, 2001-02-27)

Using both confocal immunofluorescence microscopy and biochemical approaches, we have examined the role of beta-arrestins in the activation and targeting of extracellular signal-regulated kinase 2 (ERK2) following stimulation ...

beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins.

Chen, W; Hu, LA; Kikuchi, A; Lefkowitz, Robert J; Miller, WE; Semenov, MV; Yanagawa, S (Proc Natl Acad Sci U S A, 2001-12-18)

One aspect of the function of the beta-arrestins is to serve as scaffold or adapter molecules coupling G-protein coupled receptors (GPCRs) to signal transduction pathways distinct from traditional second messenger pathways. ...