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Potentially functional polymorphisms in the ERCC2 gene and risk of esophageal squamous cell carcinoma in Chinese populations.
(Scientific reports, 2014-01)
ERCC2 is indispensable for nucleotide excision repair pathway, and its functional
polymorphisms may be associated with cancer risk. In a large case-control study of
1126 esophageal squamous cell carcinomas (ESCC) patients ...
Polymorphisms in the mTOR gene and risk of sporadic prostate cancer in an Eastern Chinese population.
(PloS one, 2013-01)
BACKGROUND: The mTOR gene regulates cell growth by controlling mRNA translation, ribosome
biogenesis, autophagy, and metabolism. Abnormally increased expression of mTOR was
associated with carcinogenesis, and its functional ...
Polymorphisms in the AKT1 and AKT2 genes and oesophageal squamous cell carcinoma risk in an Eastern Chinese population.
(Journal of cellular and molecular medicine, 2016-04)
Ethnic Han Chinese are at high risk of developing oesophageal squamous cell carcinoma
(ESCC). Aberrant activation of the AKT signalling pathway is involved in many cancers,
including ESCC. Some single nucleotide polymorphisms ...
Genetic variant rs4072037 of MUC1 and gastric cancer risk in an Eastern Chinese population.
(Oncotarget, 2016-03)
Published data on the association between the MUC1 rs4072037A > G polymorphism and
gastric cancer (GCa) risk were inconclusive. To derive a more precise estimation of
the association, we conducted a large GCa study of 1,124 ...
Potentially functional polymorphisms in the CASP7 gene contribute to gastric adenocarcinoma susceptibility in an eastern Chinese population.
(PloS one, 2013-01)
BACKGROUND: Caspase 7 (CASP7) is an important regulator and executioner in the apoptosis
pathway and plays a crucial role in cancer development and progression. However, few
studies have evaluated associations between functional ...
Genetic variant of PRKAA1 and gastric cancer risk in an eastern Chinese population.
(Oncotarget, 2015-12)
Published data on the association between PRKAA1 rs13361707 T > C polymorphism and
gastric cancer (GCa) susceptibility were inconclusive. To derive a more precise estimation
of the association, we conducted a large-scale ...
Polymorphisms in nucleotide excision repair genes and risk of primary prostate cancer in Chinese Han populations.
(Oncotarget, 2017-04)
Genetic variants of nucleotide excision repair (NER) genes have been extensively investigated
for their roles in the development of prostate cancer (PCa); however, the published
results have been inconsistent. In a hospital-based ...
Polymorphisms in the ERCC5 gene and risk of esophageal squamous cell carcinoma (ESCC) in Eastern Chinese populations.
(PloS one, 2012-01)
BACKGROUND: Excision repair cross complementing group 5 (ERCC5 or XPG) plays an important
role in regulating DNA excision repair; its functional single nucleotide polymorphisms
(SNPs) may alter DNA repair capacity and thus ...
A Functional Polymorphism (rs2494752) in the AKT1 Promoter Region and Gastric Adenocarcinoma Risk in an Eastern Chinese Population.
(Scientific reports, 2016-01-28)
AKT is an important signal transduction protein that plays a crucial role in cancer
development. Therefore, we evaluated associations between single nucleotide polymorphisms
(SNPs) in the AKT promoter region and gastric ...
PSCA polymorphisms and gastric cancer susceptibility in an eastern Chinese population.
(Oncotarget, 2016-02)
The prostate stem cell antigen (PSCA) gene, which encodes a prostate-specific antigen
(PSA), was identified as a gene involved in cell adhesion and proliferation. The associations
between the PSCA rs2294008 and rs2976392 ...