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Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection.

Barki-Harrington, L; Chen, J; Le Corvoisier, P; Lefkowitz, Robert J; Lemaire, A; Naga Prasad, SV; Noma, T; ... (11 authors) (J Clin Invest, 2007-09)

Deleterious effects on the heart from chronic stimulation of beta-adrenergic receptors (betaARs), members of the 7 transmembrane receptor family, have classically been shown to result from Gs-dependent adenylyl ...

Level of beta-adrenergic receptor kinase 1 inhibition determines degree of cardiac dysfunction after chronic pressure overload-induced heart failure.

Koch, Walter J; Lefkowitz, Robert J; Naga Prasad, SV; Rockman, Howard A; Tachibana, H (Circulation, 2005-02-08)

BACKGROUND: Heart failure is characterized by abnormalities in beta-adrenergic receptor (betaAR) signaling, including increased level of myocardial betaAR kinase 1 (betaARK1). Our previous studies have shown that inhibition ...