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Genetic variants of p27 and p21 as predictors for risk of second primary malignancy in patients with index squamous cell carcinoma of head and neck.

Liu, Zhensheng; Wei, Qingyi; Wang, Zhongqiu; Sturgis, Erich M; Zhang, Fenghua; Lei, Dapeng; Xu, Li; ... (9 authors) (Molecular cancer, 2012-03-26)

Cell cycle deregulation is common in human cancer, and alterations of p27 and p21, two critical cell cycle regulators, have been implicated in the development of many human malignancies. Therefore, we hypothesize that p27 ...

Association between novel PLCE1 variants identified in published esophageal cancer genome-wide association studies and risk of squamous cell carcinoma of the head and neck.

Liu, Zhensheng; Wei, Qingyi; Ma, Hongxia; Wang, Li-E; Sturgis, Erich M (BMC cancer, 2011-06-20)

Phospholipase C epsilon 1 (PLCE1) (an effector of Ras) belonging to the phospholipase family plays crucial roles in carcinogenesis and progression of several cancers, including squamous cell carcinoma of the head and neck ...

Genetic variants of NOXA and MCL1 modify the risk of HPV16-associated squamous cell carcinoma of the head and neck.

Liu, Zhensheng; Wei, Qingyi; Zhou, Ziyuan; Sturgis, Erich M; Wang, Li-E; Li, Guojun (BMC cancer, 2012-05)

The cooperation between phorbol 12-myristate 13-acetate induced protein 1 (NOXA) and myeloid cell leukemia 1 (MCL1) is critical in the intrinsic apoptotic pathway. Human papillomavirus 16 (HPV16), by inducing p53 and pRb-E2F ...

Association between a rare novel TP53 variant (rs78378222) and melanoma, squamous cell carcinoma of head and neck and lung cancer susceptibility in non-Hispanic Whites.

Wei, Qingyi; Liu, Zhensheng; Guan, Xiaoxiang; Wang, Li-E; Sturgis, Erich M (Journal of cellular and molecular medicine, 2013-07)

Recently, several studies have investigated the association between a newly reported rare functional single nucleotide polymorphism (SNP) in TP53 (rs78378222) and cancer risk, but generated inconsistent findings. The present ...

Associations between expression levels of nucleotide excision repair proteins in lymphoblastoid cells and risk of squamous cell carcinoma of the head and neck.

Troy, Jesse; Lee, Walter; Liu, Zhensheng; Wei, Qingyi; Han, Peng; Liu, Hongliang; Shi, Qiong; ... (10 authors) (Molecular carcinogenesis, 2018-06)

Squamous cell carcinoma of head and neck (SCCHN) is one of the most common malignancies worldwide, and nucleotide excision repair (NER) is involved in SCCHN susceptibility. In this analysis of 349 newly diagnosed SCCHN patients ...