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Sinus Node Dysfunction Is Associated With Higher Symptom Burden and Increased Comorbid Illness: Results From the ORBIT-AF Registry.

Chang, P; Fonarow, GC; Freeman, J; Gersh, Bernard John; Go, AS; Jackson, Larry Ronald II; Kim, SH; ... (14 authors) (Clin Cardiol, 2016-02)

BACKGROUND: Patients with sinus node dysfunction (SND) have increased risk of atrial tachyarrhythmias, including atrial fibrillation (AF). To date, treatment patterns and outcomes of patients with SND and AF have not been ...

Heart rate is associated with progression of atrial fibrillation, independent of rhythm.

Chang, P; Fonarow, GC; Freeman, JV; Gersh, Bernard John; Holmqvist, Fredrik Nils; Kim, S; Kowey, Peter R; ... (15 authors) (Heart, 2015-06)

OBJECTIVE: Atrial fibrillation (AF) often progresses from paroxysmal or persistent to more sustained forms, but the rate and predictors of AF progression in clinical practice are not well described. METHODS: Using the Outcomes ...

Early adoption of dabigatran and its dosing in US patients with atrial fibrillation: results from the outcomes registry for better informed treatment of atrial fibrillation.

Ansell, J; Chang, P; Ezekowitz, MD; Fonarow, GC; Gersh, Bernard John; Holmes, DaJuanicia; Hylek, EM; ... (15 authors) (J Am Heart Assoc, 2013-11-25)

BACKGROUND: Dabigatran is a novel oral anticoagulant approved for thromboprophylaxis in atrial fibrillation. Adoption patterns of this new agent in community practice are unknown. METHODS AND RESULTS: We studied patterns ...

The ORBIT bleeding score: a simple bedside score to assess bleeding risk in atrial fibrillation.

Ansell, JE; Chang, P; Fonarow, GC; Gersh, Bernard John; Hylek, EM; Kowey, Peter R; Mahaffey, Kenneth William; ... (13 authors) (Eur Heart J, 2015-12-07)

BACKGROUND: Therapeutic decisions in atrial fibrillation (AF) are often influenced by assessment of bleeding risk. However, existing bleeding risk scores have limitations. OBJECTIVES: We sought to develop and validate a ...

Increased Heart Rate Is Associated With Higher Mortality in Patients With Atrial Fibrillation (AF): Results From the Outcomes Registry for Better Informed Treatment of AF (ORBIT-AF).

Chang, P; Fonarow, GC; Gersh, Bernard John; Holmqvist, Fredrik Nils; Hylek, E; Kim, S; Kowey, Peter R; ... (15 authors) (J Am Heart Assoc, 2015-09-14)

BACKGROUND: Most patients with atrial fibrillation (AF) require rate control; however, the optimal target heart rate remains under debate. We aimed to assess rate control and subsequent outcomes among patients with permanent ...