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Diesel exhaust particles activate the matrix-metalloproteinase-1 gene in human bronchial epithelia in a beta-arrestin-dependent manner via activation of RAS.

Brinckerhoff, CE; Cho, SH; Ghio, Andrew J; Li, J; Liedtke, Wolfgang Bernhard; Simon, SA (Environ Health Perspect, 2009-03)

BACKGROUND: Diesel exhaust particles (DEPs) are globally relevant air pollutants that exert a detrimental human health impact. However, mechanisms of damage by DEP exposure to human respiratory health and human susceptibility ...