Now showing items 1-6 of 6
A meta-analysis of four genome-wide association studies of survival to age 90 years or older: the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium.
(J Gerontol A Biol Sci Med Sci, 2010-05)
BACKGROUND: Genome-wide association studies (GWAS) may yield insights into longevity. METHODS: We performed a meta-analysis of GWAS in Caucasians from four prospective cohort studies: the Age, Gene/Environment Susceptibi...
Low tobacco-related cancer incidence in offspring of long-lived siblings: a comparison with Danish national cancer registry data.
(Ann Epidemiol, 2015-08)
PURPOSE: Familial clustering of longevity is well documented and includes both genetic and other familial factors, but the specific underlying mechanisms are largely unknown. We examined whether low incidence of specific ...
Perceived stress and biological risk: is the link stronger in Russians than in Taiwanese and Americans?
Allostatic load theory implies a relationship between exposure to psychological stress and multi-system physiological dysregulation. We used data from population-based samples of men and women in Russia (Moscow; n = 1800; ...
DNA methylation age is associated with mortality in a longitudinal Danish twin study.
(Aging Cell, 2016-02)
An epigenetic profile defining the DNA methylation age (DNAm age) of an individual has been suggested to be a biomarker of aging, and thus possibly providing a tool for assessment of health and mortality. In this study, ...
Cancer and longevity--is there a trade-off? A study of cooccurrence in Danish twin pairs born 1900-1918.
(J Gerontol A Biol Sci Med Sci, 2012-05)
BACKGROUND: Animal models and a few human studies have suggested a complex interaction between cancer risk and longevity indicating a trade-off where low cancer risk is associated with accelerating aging phenotypes and, ...
Losses of expected lifetime in the United States and other developed countries: methods and empirical analyses.
Patterns of diversity in age at death are examined using e (†), a dispersion measure that equals the average expected lifetime lost at death. We apply two methods for decomposing differences in e (†). The first method estimates ...