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MRP3: a molecular target for human glioblastoma multiforme immunotherapy.
(BMC Cancer, 2010-09-01)
BACKGROUND: Glioblastoma multiforme (GBM) is refractory to conventional therapies.
To overcome the problem of heterogeneity, more brain tumor markers are required for
prognosis and targeted therapy. We have identified and ...
EGFRvIII-specific chimeric antigen receptor T cells migrate to and kill tumor deposits infiltrating the brain parenchyma in an invasive xenograft model of glioblastoma.
(PLoS One, 2014)
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults and
is uniformly lethal. T-cell-based immunotherapy offers a promising platform for treatment
given its potential to specifically target tumor ...
Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients.
(Nature, 2015-03-19)
After stimulation, dendritic cells (DCs) mature and migrate to draining lymph nodes
to induce immune responses. As such, autologous DCs generated ex vivo have been pulsed
with tumour antigens and injected back into patients ...
Multiple phenotypic changes in mice after knockout of the B3gnt5 gene, encoding Lc3 synthase--a key enzyme in lacto-neolacto ganglioside synthesis.
(BMC Dev Biol, 2010-11-18)
BACKGROUND: Ganglioside biosynthesis occurs through a multi-enzymatic pathway which
at the lactosylceramide step is branched into several biosynthetic series. Lc3 synthase
utilizes a variety of galactose-terminated glycolipids ...
MRP3: a molecular target for human glioblastoma multiforme immunotherapy.
(BMC Cancer, 2010-09-01)
BACKGROUND: Glioblastoma multiforme (GBM) is refractory to conventional therapies.
To overcome the problem of heterogeneity, more brain tumor markers are required for
prognosis and targeted therapy. We have identified and ...
Targeting A20 decreases glioma stem cell survival and tumor growth.
(PLoS Biol, 2010-02-23)
Glioblastomas are deadly cancers that display a functional cellular hierarchy maintained
by self-renewing glioblastoma stem cells (GSCs). GSCs are regulated by molecular pathways
distinct from the bulk tumor that may be ...