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Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies.

Soerensen, M; Dato, S; Tan, Q; Thinggaard, M; Kleindorp, R; Beekman, M; Jacobsen, R; ... (19 authors) (Exp Gerontol, 2012-05)

Here we explore association with human longevity of common genetic variation in three major candidate pathways: GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidants by investigating 1273 tagging ...

Low tobacco-related cancer incidence in offspring of long-lived siblings: a comparison with Danish national cancer registry data.

Christensen, Kaare; Franceschi, Claudio; Honig, LS; Kirkwood, TBL; McGue, M; Passarino, G; Pedersen, JK; ... (10 authors) (Ann Epidemiol, 2015-08)

PURPOSE: Familial clustering of longevity is well documented and includes both genetic and other familial factors, but the specific underlying mechanisms are largely unknown. We examined whether low incidence of specific ...

A meta-analysis of four genome-wide association studies of survival to age 90 years or older: the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium.

Arnold, AM; Aspelund, T; Aulchenko, YS; Benjamin, EJ; Christensen, Kaare; Christiansen, L; D'Agostino, RB; ... (43 authors) (J Gerontol A Biol Sci Med Sci, 2010-05)

BACKGROUND: Genome-wide association studies (GWAS) may yield insights into longevity. METHODS: We performed a meta-analysis of GWAS in Caucasians from four prospective cohort studies: the Age, Gene/Environment Susceptibi...

Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity.

Soerensen, M; Dato, S; Tan, Q; Thinggaard, M; Kleindorp, R; Beekman, M; Suchiman, HED; ... (19 authors) (Age (Dordr), 2013-04)

In this study, we investigated 102 single-nucleotide polymorphisms (SNPs) covering the common genetic variation in 16 genes recurrently regarded as candidates for human longevity: APOE; ACE; CETP; HFE; IL6; IL6R; MTHFR; ...

Cancer and longevity--is there a trade-off? A study of cooccurrence in Danish twin pairs born 1900-1918.

Christensen, Kaare; Pedersen, JK; Hjelmborg, JVB; Vaupel, James Walton; Stevnsner, T; Holm, NV; Skytthe, A (J Gerontol A Biol Sci Med Sci, 2012-05)

BACKGROUND: Animal models and a few human studies have suggested a complex interaction between cancer risk and longevity indicating a trade-off where low cancer risk is associated with accelerating aging phenotypes and, ...

Design, recruitment, logistics, and data management of the GEHA (Genetics of Healthy Ageing) project.

Balard, F; Beekman, M; Bezrukov, V; Blanche, H; Bolund, L; Broczek, K; Carru, C; ... (59 authors) (Exp Gerontol, 2011-11)

In 2004, the integrated European project GEHA (Genetics of Healthy Ageing) was initiated with the aim of identifying genes involved in healthy ageing and longevity. The first step in the project was the recruitment of more ...