Now showing items 1-10 of 202
Species-specific endogenous retroviruses shape the transcriptional network of the human tumor suppressor protein p53
(Proceedings of the National Academy of Sciences, 2007-11-20)
Thousands of human mobile element fragments undergo strong purifying selection near developmental genes.
(Proceedings of the National Academy of Sciences of the United States of America, 2007-05)
At least 5% of the human genome predating the mammalian radiation is thought to have evolved under purifying selection, yet protein-coding and related untranslated exons occupy at most 2% of the genome. Thus, the majority ...
Strategic use of statistical thinking in drug development.
(Stat Med, 2000-12-15)
The role of the statistician and statistical thinking in the pharmaceutical industry has evolved greatly in the last four or five decades. Regulatory developments and the changing face of the science of drug development ...
Differentiating sensitivity of post-stimulus undershoot under diffusion weighting: implication of vascular and neuronal hierarchy.
(PLoS One, 2008-08-13)
The widely used blood oxygenation level dependent (BOLD) signal during brain activation, as measured in typical fMRI methods, is composed of several distinct phases, the last of which, and perhaps the least understood, is ...
3Conserved cryptic recombination signals in V kappa gene segments are cleaved in small pre-B cells
(BMC IMMUNOLOGY, 2009-06-25)
A nucleosome-guided map of transcription factor binding sites in yeast.
(PLoS Comput Biol, 2007-11)
Finding functional DNA binding sites of transcription factors (TFs) throughout the genome is a crucial step in understanding transcriptional regulation. Unfortunately, these binding sites are typically short and degenerate, ...
Perceived discrimination and health: a meta-analytic review.
(Psychol Bull, 2009-07)
Perceived discrimination has been studied with regard to its impact on several types of health effects. This meta-analysis provides a comprehensive account of the relationships between multiple forms of perceived discrimination ...
A framework for integrating the songbird brain.
(J Comp Physiol A Neuroethol Sens Neural Behav Physiol, 2002-12)
Biological systems by default involve complex components with complex relationships. To decipher how biological systems work, we assume that one needs to integrate information over multiple levels of complexity. The songbird ...
Analysis of the mouse transcriptome for genes involved in the function of the nervous system.
(Genome Res, 2003-06)
We analyzed the mouse Representative Transcript and Protein Set for molecules involved in brain function. We found full-length cDNAs of many known brain genes and discovered new members of known brain gene families, including ...
Composition and topographic organization of signals sent from the frontal eye field to the superior colliculus.
(J Neurophysiol, 2000-04)
The frontal eye field (FEF) and superior colliculus (SC) contribute to saccadic eye movement generation, and much of the FEF's oculomotor influence may be mediated through the SC. The present study examined the composition ...