Now showing items 1-10 of 320
Black cohosh increases metastatic mammary cancer in transgenic mice expressing c-erbB2.
(Cancer research, 2008-10)
Black cohosh is an herbal extract that is often used as an alternative to estrogen-based replacement therapies to treat hot flushes that frequently accompany the transition to menopause. Although cancer-free women as well ...
Emergency physician high pretest probability for acute coronary syndrome correlates with adverse cardiovascular outcomes.
(Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2009-08)
OBJECTIVES: The value of unstructured physician estimate of risk for disease processes, other than acute coronary syndrome (ACS), has been demonstrated. The authors sought to evaluate the predictive value of unstructured ...
Species-specific endogenous retroviruses shape the transcriptional network of the human tumor suppressor protein p53
(Proceedings of the National Academy of Sciences, 2007-11-20)
Thousands of human mobile element fragments undergo strong purifying selection near developmental genes.
(Proceedings of the National Academy of Sciences of the United States of America, 2007-05)
At least 5% of the human genome predating the mammalian radiation is thought to have evolved under purifying selection, yet protein-coding and related untranslated exons occupy at most 2% of the genome. Thus, the majority ...
Effects of nocistatin and nocistatin (10-17) on nociceptin in antagonizing endomorphin-1 and endomorphin-2 analgesia in mice
(Yaoxue Xuebao, 2002-11-01)
AIM: To investigate the effects of nocistatin and nocistatin (10-17) on nociceptin in antagonizing endomorphin-1 or endomorphin-2 analgesia in mice. METHODS: Nocistatin and nocistatin (10-17) were synthesized by solid-phase ...
The effects of the synthetic nocistatin on blood vessel activities
(Chinese Science Bulletin, 2001-01-01)
Nocistatin was synthesized by the solid-phase peptide synthesis method. Its effects on rat systemic arterial pressure; rat hindquarter vascular bed resistance; tension of rabbit pectoral, abdominal, femoral aorta muscle ...
Strategic use of statistical thinking in drug development.
(Stat Med, 2000-12-15)
The role of the statistician and statistical thinking in the pharmaceutical industry has evolved greatly in the last four or five decades. Regulatory developments and the changing face of the science of drug development ...
Differentiating sensitivity of post-stimulus undershoot under diffusion weighting: implication of vascular and neuronal hierarchy.
(PLoS One, 2008-08-13)
The widely used blood oxygenation level dependent (BOLD) signal during brain activation, as measured in typical fMRI methods, is composed of several distinct phases, the last of which, and perhaps the least understood, is ...
3Conserved cryptic recombination signals in V kappa gene segments are cleaved in small pre-B cells
(BMC IMMUNOLOGY, 2009-06-25)