Now showing items 1-10 of 79
Vaccine-induced memory CD8+ T cells provide clinical benefit in HER2 expressing breast cancer: a mouse to human translational study.
(Clinical cancer research : an official journal of the American Association for Cancer Research, 2019-01-11)
PURPOSE:Immune-based therapy for metastatic breast cancer has had limited success, particularly in molecular subtypes with low somatic mutations rates. Strategies to augment T cell infiltration of tumors include vaccines ...
The INTUIT Study: Investigating Neuroinflammation Underlying Postoperative Cognitive Dysfunction.
(Journal of the American Geriatrics Society, 2019-01-23)
BACKGROUND/OBJECTIVES:Every year, up to 40% of the more than 16 million older Americans who undergo anesthesia/surgery develop postoperative cognitive dysfunction (POCD) or delirium. Each of these distinct syndromes is associated ...
Towards prevention of post-traumatic osteoarthritis: report from an international expert working group on considerations for the design and conduct of interventional studies following acute knee injury.
(Osteoarthritis and cartilage, 2019-01)
OBJECTIVE:There are few guidelines for clinical trials of interventions for prevention of post-traumatic osteoarthritis (PTOA), reflecting challenges in this area. An international multi-disciplinary expert group including ...
Increased predominance of HIV-1 CRF01_AE and its recombinants in the Philippines.
(The Journal of general virology, 2019-01-24)
The growth rate of new HIV infections in the Philippines was the fastest of any countries in the Asia-Pacific region between 2010 and 2016. To date, HIV-1 subtyping results in the Philippines have been determined ...
Genetic variants in ELOVL2 and HSD17B12 predict melanoma-specific survival.
(International journal of cancer, 2019-02-08)
Fatty acids play a key role in cellular bioenergetics, membrane biosynthesis and intracellular signaling processes and thus may be involved in cancer development and progression. In the present study, we comprehensively ...
Recommendations towards standards for quantitative MRI (qMRI) and outstanding needs.
(Journal of magnetic resonance imaging : JMRI, 2019-01-24)
LEVEL OF EVIDENCE:5 Technical Efficacy: Stage 5 J. Magn. Reson. Imaging 2019.
Genetic Variants in RUNX3, AMD1 and MSRA in the Methionine Metabolic Pathway and Survival in Non-small Cell Lung Cancer Patients.
(International journal of cancer, 2019-01-16)
Abnormal methionine dependence in cancer cells has led to methionine restriction as a potential therapeutic strategy. We hypothesized that genetic variants involved in methionine-metabolic genes are associated with survival ...
MRGPR-mediated activation of local mast cells clears cutaneous bacterial infection and protects against reinfection.
(Science advances, 2019-01-02)
Mast cells (MCs) are strategically distributed at barrier sites and prestore various immunocyte-recruiting cytokines, making them ideal targets for selective activation to treat peripheral infections. Here, we report that ...
Genetics of Childhood Steroid Sensitive Nephrotic Syndrome: An Update.
(Frontiers in pediatrics, 2019-01-29)
Advances in genome science in the last 20 years have led to the discovery of over 50 single gene causes and genetic risk loci for steroid resistant nephrotic syndrome (SRNS). Despite these advances, the genetic architecture ...
Targeting androgen receptor-independent pathways in therapy-resistant prostate cancer.
(Asian journal of urology, 2019-01)
Since androgen receptor (AR) signaling is critically required for the development of prostate cancer (PCa), targeting AR axis has been the standard treatment of choice for advanced and metastatic PCa. Unfortunately, although ...