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beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi.
(Proc Natl Acad Sci U S A, 2003-02-04)
Phosphorylation of the beta(2) adrenoreceptor (beta(2)AR) by cAMP-activated protein
kinase A (PKA) switches its predominant coupling from stimulatory guanine nucleotide
regulatory protein (G(s)) to inhibitory guanine nucleotide ...
Enhanced rewarding properties of morphine, but not cocaine, in beta(arrestin)-2 knock-out mice.
(J Neurosci, 2003-11-12)
The reinforcing and psychomotor effects of morphine involve opiate stimulation of
the dopaminergic system via activation of mu-opioid receptors (muOR). Both mu-opioid
and dopamine receptors are members of the G-protein-coupled ...
β-Arrestin-2 regulates the development of allergic asthma
(Journal of Clinical Investigation, 2003-08-01)
Asthma is a chronic inflammatory disorder of the airways that is coordinated by Th2
cells in both human asthmatics and animal models of allergic asthma. Migration of
Th2 cells to the lung is key to their inflammatory function ...
Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.
(Proc Natl Acad Sci U S A, 2003-09-16)
Stimulation of a mutant angiotensin type 1A receptor (DRY/AAY) with angiotensin II
(Ang II) or of a wild-type receptor with an Ang II analog ([sarcosine1,Ile4,Ile8]Ang
II) fails to activate classical heterotrimeric G protein ...
A magnificent time with the "magnificent seven" transmembrane spanning receptors.
(Circ Res, 2003-03-07)
Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference.
(Proc Natl Acad Sci U S A, 2003-02-18)
Beta-arrestins bind to activated G protein-coupled receptor kinase-phosphorylated
receptors, which leads to their desensitization with respect to G proteins, internalization
via clathrin-coated pits, and signaling via a ...
Beta-arrestin-2 regulates the development of allergic asthma.
(J Clin Invest, 2003-08)
Asthma is a chronic inflammatory disorder of the airways that is coordinated by Th2
cells in both human asthmatics and animal models of allergic asthma. Migration of
Th2 cells to the lung is key to their inflammatory function ...
Purification, crystallization and preliminary X-ray diffraction studies of a complex between G protein-coupled receptor kinase 2 and Gbeta1gamma2.
(Acta Crystallogr D Biol Crystallogr, 2003-05)
G protein-coupled receptor kinase 2 (GRK2) phosphorylates activated G protein-coupled
receptors (GPCRs), which ultimately leads to their desensitization and/or downregulation.
The enzyme is recruited to the plasma membrane ...
An interview with Professor Robert J. Lefkowitz, M.D. Interview by Vicki Glaser.
(Assay Drug Dev Technol, 2003-04)
Robert J. Lefkowitz, M.D., is James B. Duke Professor of Medicine and Professor of
Biochemistry at the Duke University Medical Center. He has been an Investigator of
the Howard Hughes Medical Institute since 1976. Dr. Lefkowitz ...