The reinforcing and psychomotor effects of morphine involve opiate stimulation of the dopaminergic system via activation of mu-opioid receptors (muOR). Both mu-opioid and dopamine receptors are members of the G-protein-coupled ...

Asthma is a chronic inflammatory disorder of the airways that is coordinated by Th2 cells in both human asthmatics and animal models of allergic asthma. Migration of Th2 cells to the lung is key to their inflammatory function ...

OBJECTIVES:We examined the prevalence and correlates of substance use, dependence, and service utilization among uninsured persons aged 12 to 64 years. METHODS:We drew study data from the 1998 National Household Survey on ...

OBJECTIVE:To examine the prevalence of psychostimulant dependence and the characteristics associated with nonmedical users' development of dependence. METHODS:The study sample was drawn from the 1995 to 1998 National Household ...

PURPOSE:To examine the association between employment status and substance use among students aged 12 to 17 years. METHODS:Secondary analysis of data from the 1995 and 1996 National Household Surveys on Drug Abuse was conducted. ...

OBJECTIVES: This study provided population estimates of mental syndromes and substance use problems and examined whether the co-occurrence of mental health and substance use problems was associated with the use of substance ...

Robert J. Lefkowitz, M.D., is James B. Duke Professor of Medicine and Professor of Biochemistry at the Duke University Medical Center. He has been an Investigator of the Howard Hughes Medical Institute since 1976. Dr. Lefkowitz ...