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Enhanced rewarding properties of morphine, but not cocaine, in beta(arrestin)-2 knock-out mice.
(J Neurosci, 2003-11-12)
The reinforcing and psychomotor effects of morphine involve opiate stimulation of
the dopaminergic system via activation of mu-opioid receptors (muOR). Both mu-opioid
and dopamine receptors are members of the G-protein-coupled ...
Beta-arrestin-2 regulates the development of allergic asthma.
(J Clin Invest, 2003-08)
Asthma is a chronic inflammatory disorder of the airways that is coordinated by Th2
cells in both human asthmatics and animal models of allergic asthma. Migration of
Th2 cells to the lung is key to their inflammatory function ...
An interview with Professor Robert J. Lefkowitz, M.D. Interview by Vicki Glaser.
(Assay Drug Dev Technol, 2003-04)
Robert J. Lefkowitz, M.D., is James B. Duke Professor of Medicine and Professor of
Biochemistry at the Duke University Medical Center. He has been an Investigator of
the Howard Hughes Medical Institute since 1976. Dr. Lefkowitz ...