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Now showing items 1-10 of 13

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β-Arrestin-2 regulates the development of allergic asthma 

Fong, AM; Lawson, BL; Lefkowitz, Robert J; Patel, DD; Savov, JD; Schwartz, David A; Walker, JKL (Journal of Clinical Investigation, 2003-08-01)
Asthma is a chronic inflammatory disorder of the airways that is coordinated by Th2 cells in both human asthmatics and animal models of allergic asthma. Migration of Th2 cells to the lung is key to their inflammatory function ...
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Enhanced rewarding properties of morphine, but not cocaine, in beta(arrestin)-2 knock-out mice. 

Bohn, Laura M; Gainetdinov, Raul R; Sotnikova, Tatyana D; Medvedev, Ivan O; Lefkowitz, Robert J; Dykstra, Linda A; Caron, Marc G (J Neurosci, 2003-11-12)
The reinforcing and psychomotor effects of morphine involve opiate stimulation of the dopaminergic system via activation of mu-opioid receptors (muOR). Both mu-opioid and dopamine receptors are members of the G-protein-coupled ...
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Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2. 

Wei, Huijun; Ahn, Seungkirl; Shenoy, Sudha K; Karnik, Sadashiva S; Hunyady, László; Luttrell, Louis M; Lefkowitz, Robert J (Proc Natl Acad Sci U S A, 2003-09-16)
Stimulation of a mutant angiotensin type 1A receptor (DRY/AAY) with angiotensin II (Ang II) or of a wild-type receptor with an Ang II analog ([sarcosine1,Ile4,Ile8]Ang II) fails to activate classical heterotrimeric G protein ...
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Beta-arrestin-2 regulates the development of allergic asthma. 

Walker, Julia KL; Fong, Alan M; Lawson, Barbara L; Savov, Jordan D; Patel, Dhavalkumar D; Schwartz, David A; Lefkowitz, Robert J (J Clin Invest, 2003-08)
Asthma is a chronic inflammatory disorder of the airways that is coordinated by Th2 cells in both human asthmatics and animal models of allergic asthma. Migration of Th2 cells to the lung is key to their inflammatory function ...
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Substance use, dependence, and service utilization among the US uninsured nonelderly population. 

Wu, Li-Tzy; Kouzis, Anthony C; Schlenger, William E (American journal of public health, 2003-12)
OBJECTIVES:We examined the prevalence and correlates of substance use, dependence, and service utilization among uninsured persons aged 12 to 64 years. METHODS:We drew study data from the 1998 National Household Survey on ...
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Psychostimulant dependence in a community sample. 

Wu, Li-Tzy; Schlenger, William E (Substance use & misuse, 2003-01)
OBJECTIVE:To examine the prevalence of psychostimulant dependence and the characteristics associated with nonmedical users' development of dependence. METHODS:The study sample was drawn from the 1995 to 1998 National Household ...
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The relationship between employment and substance use among students aged 12 to 17. 

Wu, Li Tzy; Schlenger, William E; Galvin, Deborah M (The Journal of adolescent health : official publication of the Society for Adolescent Medicine, 2003-01)
PURPOSE:To examine the association between employment status and substance use among students aged 12 to 17 years. METHODS:Secondary analysis of data from the 1995 and 1996 National Household Surveys on Drug Abuse was conducted. ...
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Use of substance abuse treatment services by persons with mental health and substance use problems. 

Wu, Li-Tzy; Ringwalt, Christopher L; Williams, Charles E (Psychiatric services (Washington, D.C.), 2003-03)
OBJECTIVES: This study provided population estimates of mental syndromes and substance use problems and examined whether the co-occurrence of mental health and substance use problems was associated with the use of substance ...
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Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference. 

Ahn, Seungkirl; Nelson, Christopher D; Garrison, Tiffany Runyan; Miller, William E; Lefkowitz, Robert J (Proc Natl Acad Sci U S A, 2003-02-18)
Beta-arrestins bind to activated G protein-coupled receptor kinase-phosphorylated receptors, which leads to their desensitization with respect to G proteins, internalization via clathrin-coated pits, and signaling via a ...
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beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi. 

Baillie, George S; Sood, Arvind; McPhee, Ian; Gall, Irene; Perry, Stephen J; Lefkowitz, Robert J; Houslay, Miles D (Proc Natl Acad Sci U S A, 2003-02-04)
Phosphorylation of the beta(2) adrenoreceptor (beta(2)AR) by cAMP-activated protein kinase A (PKA) switches its predominant coupling from stimulatory guanine nucleotide regulatory protein (G(s)) to inhibitory guanine nucleotide ...
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AuthorLefkowitz, Robert J (8)Schlenger, William E (3)Wu, Li-Tzy (3)Ahn, Seungkirl (2)Baillie, George S (1)Barnhill, Jennifer F (1)Bohn, Laura M (1)Capel, W Darrell (1)Caron, Marc G (1)Dykstra, Linda A (1)... View MoreDate Issued
2003 (13)
Type
Journal article (13)
SubjectHumans (9)Male (7)Animals (6)Arrestins (5)beta-Arrestins (5)Female (5)Adolescent (4)Cell Line (4)Prevalence (4)Substance-Related Disorders (4)... View MoreAffiliation of Duke Author(s)
Clinical Science Departments (13)
Duke (13)
Institutes and Centers (13)
Medicine (13)
School of Medicine (13)Basic Science Departments (9)Biochemistry (9)Chemistry (9)Duke Cancer Institute (9)Medicine, Cardiology (9)... View More
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