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Reported lifetime aberrant drug-taking behaviors are predictive of current substance use and mental health problems in primary care patients.
(Pain Med, 2008-11)
BACKGROUND: The aim of this report is to determine the frequency of aberrant drug
behaviors and their relationship to substance abuse disorders in a large primary sample
of patients receiving opioids for chronic pain. METHODS: ...
The design of an observational study of hypertension management, adherence and pressure control in Blood Pressure Success Zone Program participants.
(Int J Clin Pract, 2008-09)
AIMS: The Blood Pressure Success Zone (BPSZ) Program, a nationwide initiative, provides
education in addition to a complimentary trial of one of three antihypertensive medications.
The BPSZ Longitudinal Observational Study ...
Oxygen for relief of dyspnoea in mildly- or non-hypoxaemic patients with cancer: a systematic review and meta-analysis.
(Br J Cancer, 2008-01-29)
The aim of this study was to determine the efficacy of palliative oxygen for relief
of dyspnoea in cancer patients. MEDLINE and EMBASE were searched for randomised controlled
trials, comparing oxygen and medical air in cancer ...
Comorbidity, age, race and stage at diagnosis in colorectal cancer: a retrospective, parallel analysis of two health systems.
(BMC Cancer, 2008-11-25)
BACKGROUND: Stage at diagnosis plays a significant role in colorectal cancer (CRC)
survival. Understanding which factors contribute to a more advanced stage at diagnosis
is vital to improving overall survival. Comorbidity, ...
An integrated approach to the prediction of chemotherapeutic response in patients with breast cancer.
(PLoS One, 2008-04-02)
BACKGROUND: A major challenge in oncology is the selection of the most effective chemotherapeutic
agents for individual patients, while the administration of ineffective chemotherapy
increases mortality and decreases quality ...
The annual ASCI meeting: does nostalgia have a future?
(J Clin Invest, 2008-04)
For many academic physician-scientists, the yearly Tri-Societies meeting of the ASCI,
AAP, and AFCR during the 1960s, '70s, and '80s was an annual rite of spring and the
focal point of the academic year. In this brief essay, ...
The genomic analysis of erythrocyte microRNA expression in sickle cell diseases.
(PLoS One, 2008-06-04)
BACKGROUND: Since mature erythrocytes are terminally differentiated cells without
nuclei and organelles, it is commonly thought that they do not contain nucleic acids.
In this study, we have re-examined this issue by analyzing ...
Gender differences in the risk of HIV infection among persons reporting abstinence, monogamy, and multiple sexual partners in northern Tanzania.
(PLoS One, 2008-08-27)
BACKGROUND: Monogamy, together with abstinence, partner reduction, and condom use,
is widely advocated as a key behavioral strategy to prevent HIV infection in sub-Saharan
Africa. We examined the association between the ...
Tissue-specific genetic control of splicing: implications for the study of complex traits.
(PLoS Biol, 2008-12-23)
Numerous genome-wide screens for polymorphisms that influence gene expression have
provided key insights into the genetic control of transcription. Despite this work,
the relevance of specific polymorphisms to in vivo expression ...
Gene expression signatures of radiation response are specific, durable and accurate in mice and humans.
(PLoS One, 2008-04-02)
BACKGROUND: Previous work has demonstrated the potential for peripheral blood (PB)
gene expression profiling for the detection of disease or environmental exposures.
METHODS AND FINDINGS: We have sought to determine the ...