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Augmentation of cardiac contractility mediated by the human beta(3)-adrenergic receptor overexpressed in the hearts of transgenic mice.

Kohout, TA; Lefkowitz, Robert J; Mao, L; McDonald, Patricia H; Perry, SJ; Rockman, Howard A; Takaoka, H (Circulation, 2001-11-13)

BACKGROUND: Stimulation of beta(1)- and beta(2)-adrenergic receptors (ARs) in the heart results in positive inotropy. In contrast, it has been reported that the beta(3)AR is also expressed in the human heart and that its ...

beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking.

Conner, DA; Kohout, TA; Lefkowitz, Robert J; Lin, FS; Perry, SJ (Proc Natl Acad Sci U S A, 2001-02-13)

The two widely coexpressed isoforms of beta-arrestin (termed beta arrestin 1 and 2) are highly similar in amino acid sequence. The beta-arrestins bind phosphorylated heptahelical receptors to desensitize and target them ...