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Clinical characteristics and 12-month outcomes of patients with valvular and non-valvular atrial fibrillation in Kenya. 

Akwanalo, CO; Bloomfield, Gerald; Chen, P-S; Emonyi, W; Heckbert, SR; Inui, TS; Kimaiyo, S; ... (16 authors) (PLoS One, 2017)
BACKGROUND: Atrial fibrillation (AF) is a major contributor to the global cardiovascular disease burden. The clinical profile and outcomes of AF patients with valvular heart diseases in sub-Saharan Africa (SSA) have not ...
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Rationale and Design of the Lung Cancer Screening Implementation. Evaluation of Patient-Centered Care Study. 

Miranda, Leah S; Datta, Santanu; Melzer, Anne C; Wiener, Renda Soylemez; Davis, James M; Tong, Betty C; Golden, Sara E; ... (8 authors) (Annals of the American Thoracic Society, 2017-10)
Screening for lung cancer using low-dose computed tomography has been demonstrated to reduce lung cancer-related mortality and is being widely implemented. Further research in this area is needed to assess the impact of ...
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Hybrid de novo genome assembly and centromere characterization of the gray mouse lemur (Microcebus murinus). 

Larsen, Peter A; Harris, R Alan; Liu, Yue; Murali, Shwetha C; Campbell, C Ryan; Brown, Adam D; Sullivan, Beth A; ... (20 authors) (BMC biology, 2017-11-16)
The de novo assembly of repeat-rich mammalian genomes using only high-throughput short read sequencing data typically results in highly fragmented genome assemblies that limit downstream applications. Here, we present an ...
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Selective inhibition of FLT3 by gilteritinib in relapsed or refractory acute myeloid leukaemia: a multicentre, first-in-human, open-label, phase 1-2 study. 

Perl, Alexander E; Altman, Jessica K; Cortes, Jorge; Smith, Catherine; Litzow, Mark; Baer, Maria R; Claxton, David; ... (26 authors) (The Lancet. Oncology, 2017-08)
BACKGROUND:Internal tandem duplication mutations in FLT3 are common in acute myeloid leukaemia and are associated with rapid relapse and short overall survival. The clinical benefit of FLT3 inhibitors in patients with acute ...
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Expanded safety analysis of pevonedistat, a first-in-class NEDD8-activating enzyme inhibitor, in patients with acute myeloid leukemia and myelodysplastic syndromes. 

Swords, RT; Watts, J; Erba, HP; Altman, JK; Maris, M; Anwer, F; Hua, Z; ... (14 authors) (Blood cancer journal, 2017-02-03)
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Post-operative opioid pain management patterns for patients who receive hip surgery. 

Cook, Chad E; Rhon, Daniel I; Lewis, Brian D; George, Steven Z (Substance abuse treatment, prevention, and policy, 2017-03-16)
Identifying optimal, post-operative opioid management strategies is a priority of health providers and government agencies. At present, there are no studies we are aware of that have formally investigated opioid prescribing ...
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The Digital Drag and Drop Pillbox: Design and Feasibility of a Skill-based Education Model to Improve Medication Management. 

Granger, Bradi B; Locke, Susan C; Bowers, Margaret; Sawyer, Tenita; Shang, Howard; Abernethy, Amy P; Bloomfield, Richard A; ... (8 authors) (The Journal of cardiovascular nursing, 2017-09)
We present the design and feasibility testing for the "Digital Drag and Drop Pillbox" (D-3 Pillbox), a skill-based educational approach that engages patients and providers, measures performance, and generates reports of ...
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Contribution of urinary tract infection to the burden of febrile illnesses in young children in rural Kenya. 

Masika, Wechuli Geoffrey; O'Meara, Wendy Prudhomme; Holland, Thomas L; Armstrong, Janice (PLoS One, 2017)
INTRODUCTION: The clinical features of UTI in young children may not localize to the urinary tract and closely resemble other febrile illnesses. In malaria endemic areas, a child presenting with fever is often treated ...
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Benefit of Ezetimibe Added to Simvastatin in Reduced Kidney Function. 

Stanifer, John W; Charytan, David M; White, Jennifer; Lokhnygina, Yuliya; Cannon, Christopher P; Roe, Matthew T; Blazing, Michael A (J Am Soc Nephrol, 2017-10)
Efficacy of statin-based therapies in reducing cardiovascular mortality in individuals with CKD seems to diminish as eGFR declines. The strongest evidence supporting the cardiovascular benefit of statins in individuals with ...
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Risk Factors for Heart Failure in Patients With Chronic Kidney Disease: The CRIC (Chronic Renal Insufficiency Cohort) Study. 

He, Jiang; Shlipak, Michael; Anderson, Amanda; Roy, Jason A; Feldman, Harold I; Kallem, Radhakrishna Reddy; Kanthety, Radhika; ... (17 authors) (Journal of the American Heart Association, 2017-05-17)
BACKGROUND:Heart failure is common in patients with chronic kidney disease. We studied risk factors for incident heart failure among 3557 participants in the CRIC (Chronic Renal Insufficiency Cohort) Study. METHODS ...
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AuthorWu, Li-Tzy (6)Peterson, Eric D (3)Xian, Ying (3)Hernandez, Adrian F (2)John, William S (2)Liang, Li (2)Pencina, Michael J (2)Xu, Haolin (2)Abernethy, Amy P (1)Aiden, Erez Lieberman (1)... View MoreDate Issued
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