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beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi.
(Proc Natl Acad Sci U S A, 2003-02-04)
Phosphorylation of the beta(2) adrenoreceptor (beta(2)AR) by cAMP-activated protein
kinase A (PKA) switches its predominant coupling from stimulatory guanine nucleotide
regulatory protein (G(s)) to inhibitory guanine nucleotide ...
Enhanced rewarding properties of morphine, but not cocaine, in beta(arrestin)-2 knock-out mice.
(J Neurosci, 2003-11-12)
The reinforcing and psychomotor effects of morphine involve opiate stimulation of
the dopaminergic system via activation of mu-opioid receptors (muOR). Both mu-opioid
and dopamine receptors are members of the G-protein-coupled ...
Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.
(Proc Natl Acad Sci U S A, 2003-09-16)
Stimulation of a mutant angiotensin type 1A receptor (DRY/AAY) with angiotensin II
(Ang II) or of a wild-type receptor with an Ang II analog ([sarcosine1,Ile4,Ile8]Ang
II) fails to activate classical heterotrimeric G protein ...
Beta-arrestin-2 regulates the development of allergic asthma.
(J Clin Invest, 2003-08)
Asthma is a chronic inflammatory disorder of the airways that is coordinated by Th2
cells in both human asthmatics and animal models of allergic asthma. Migration of
Th2 cells to the lung is key to their inflammatory function ...