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Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2. 

Wei, Huijun; Ahn, Seungkirl; Shenoy, Sudha K; Karnik, Sadashiva S; Hunyady, László; Luttrell, Louis M; Lefkowitz, Robert J (Proc Natl Acad Sci U S A, 2003-09-16)
Stimulation of a mutant angiotensin type 1A receptor (DRY/AAY) with angiotensin II (Ang II) or of a wild-type receptor with an Ang II analog ([sarcosine1,Ile4,Ile8]Ang II) fails to activate classical heterotrimeric G protein ...
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beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi. 

Baillie, George S; Sood, Arvind; McPhee, Ian; Gall, Irene; Perry, Stephen J; Lefkowitz, Robert J; Houslay, Miles D (Proc Natl Acad Sci U S A, 2003-02-04)
Phosphorylation of the beta(2) adrenoreceptor (beta(2)AR) by cAMP-activated protein kinase A (PKA) switches its predominant coupling from stimulatory guanine nucleotide regulatory protein (G(s)) to inhibitory guanine nucleotide ...
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A magnificent time with the "magnificent seven" transmembrane spanning receptors. 

Lefkowitz, Robert J (Circ Res, 2003-03-07)

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AuthorLefkowitz, Robert J (3)Ahn, Seungkirl (1)Baillie, George S (1)Gall, Irene (1)Houslay, Miles D (1)Hunyady, László (1)Karnik, Sadashiva S (1)Luttrell, Louis M (1)McPhee, Ian (1)Perry, Stephen J (1)... View MoreDate Issued
2003 (3)
TypeJournal article (3)Subject
Animals (3)
Humans (3)
Arrestins (2)beta-Arrestins (2)Cell Line (2)Enzyme Activation (2)Enzyme Inhibitors (2)Rats (2)Receptors, Adrenergic, beta (2)3',5'-Cyclic-AMP Phosphodiesterases (1)... View MoreAffiliation of Duke Author(s)Basic Science Departments (3)Biochemistry (3)Chemistry (3)
Clinical Science Departments (3)
Duke (3)Duke Cancer Institute (3)
Institutes and Centers (3)
Medicine (3)
Medicine, Cardiology (3)Pathology (3)... View More
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