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Plerixafor (a CXCR4 antagonist) following myeloablative allogeneic hematopoietic stem cell transplantation enhances hematopoietic recovery.

Chao, Nelson J; Chhabra, S; Corbet, K; Costa, L; Gasparetto, C; Green, MMB; Horwitz, A; ... (18 authors) (J Hematol Oncol, 2018-03-04)

BACKGROUND: The binding of CXCR4 with its ligand (stromal-derived factor-1) maintains hematopoietic stem/progenitor cells (HSPCs) in a quiescent state. We hypothesized that blocking CXCR4/SDF-1 interaction after hematopoietic ...

Antibiotic overuse for acute respiratory tract infections in Sri Lanka: a qualitative study of outpatients and their physicians.

Arachchi, WK; Bodinayake, Champica K; Dabrera, T; Nagahawatte, A; Østbye, Truls; Sooriyaarachchi, A; Stewart, K; ... (10 authors) (BMC Fam Pract, 2018-03-01)

BACKGROUND: Acute respiratory tract infections (ARTIs) are a common reason for antibiotic overuse worldwide. We previously showed that over 80% of outpatients presenting to a tertiary care hospital in Sri Lanka ...