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Associations of potentially functional variants in IL-6, JAKs and STAT3 with gastric cancer risk in an eastern Chinese population.
(Oncotarget, 2016-05)
The interleukin-6 (IL-6)/JAK/STAT3 signaling pathway plays a central role in inflammation-mediated
cancers, including gastric cancer (GCa). We evaluated associations between 10 potentially
functional single nucleotide ...
A novel inflammatory biomarker, GlycA, associates with disease activity in rheumatoid arthritis and cardio-metabolic risk in BMI-matched controls.
(Arthritis Res Ther, 2016-04-12)
BACKGROUND: RA and CVD both have inflammation as part of the underlying biology. Our
objective was to explore the relationships of GlycA, a measure of glycosylated acute
phase proteins, with inflammation and cardiometabolic ...
Polymorphisms in the AKT1 and AKT2 genes and oesophageal squamous cell carcinoma risk in an Eastern Chinese population.
(Journal of cellular and molecular medicine, 2016-04)
Ethnic Han Chinese are at high risk of developing oesophageal squamous cell carcinoma
(ESCC). Aberrant activation of the AKT signalling pathway is involved in many cancers,
including ESCC. Some single nucleotide polymorphisms ...
Site disparities in apoptotic variants as predictors of risk for second primary malignancy in patients with squamous cell carcinoma of the head and neck.
(BMC cancer, 2016-02-08)
FAS/FASL promoter variants are considered in altering transcriptional activity of
those genes and consequently alter regulation of cell death. However, no studies have
investigated whether tumor sites contribute ...
PSCA polymorphisms and gastric cancer susceptibility in an eastern Chinese population.
(Oncotarget, 2016-02)
The prostate stem cell antigen (PSCA) gene, which encodes a prostate-specific antigen
(PSA), was identified as a gene involved in cell adhesion and proliferation. The associations
between the PSCA rs2294008 and rs2976392 ...
A Functional Polymorphism (rs2494752) in the AKT1 Promoter Region and Gastric Adenocarcinoma Risk in an Eastern Chinese Population.
(Scientific reports, 2016-01-28)
AKT is an important signal transduction protein that plays a crucial role in cancer
development. Therefore, we evaluated associations between single nucleotide polymorphisms
(SNPs) in the AKT promoter region and gastric ...
How Reliable are Patient-Reported Rehospitalizations? Implications for the Design of Future Practical Clinical Studies.
(J Am Heart Assoc, 2016-01-25)
BACKGROUND: Longitudinal clinical investigations often rely on patient reports to
screen for postdischarge adverse outcomes events, yet few studies have examined the
accuracy of such patient reports. METHODS AND RESULTS: ...
Genetic variant rs4072037 of MUC1 and gastric cancer risk in an Eastern Chinese population.
(Oncotarget, 2016-03)
Published data on the association between the MUC1 rs4072037A > G polymorphism and
gastric cancer (GCa) risk were inconclusive. To derive a more precise estimation of
the association, we conducted a large GCa study of 1,124 ...
Associations of genotypes and haplotypes of IL-17 with risk of gastric cancer in an eastern Chinese population.
(Oncotarget, 2016-12)
Interleukin-17 plays a crucial role in inflammation-related carcinogenesis. We hypothesize
that genetic variants in IL-17 are associated with gastric cancer (GCa) risk, and
we genotyped five potentially functional single ...
Risks and Benefits Associated With Prestroke Antiplatelet Therapy Among Patients With Acute Ischemic Stroke Treated With Intravenous Tissue Plasminogen Activator.
(JAMA neurology, 2016-01)
Intravenous tissue plasminogen activator (tPA) is known to improve outcomes in ischemic
stroke; however, many patients may have been receiving antiplatelet therapy before
acute ischemic stroke and could face an increased ...