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[More people live to be very old and with a better functioning].
(Ugeskr Laeger, 2013-10-07)
Death rates for 80+-year-olds are now half of what they were after WWII. The chance
of living past 90 years has gone up by roughly 30% per decade for people born in Denmark
in 1895, 1905, and 1915 - and the later cohorts ...
The Danish Twin Registry: linking surveys, national registers, and biological information.
(Twin Res Hum Genet, 2013-02)
Over the last 60 years, the resources and the research in the Danish Twin Registry
(DTR) have periodically been summarized. Here, we give a short overview of the DTR
and a more comprehensive description of new developments ...
Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies.
(Exp Gerontol, 2012-05)
Here we explore association with human longevity of common genetic variation in three
major candidate pathways: GH/IGF-1/insulin signaling, DNA damage signaling and repair
and pro/antioxidants by investigating 1273 tagging ...
Low tobacco-related cancer incidence in offspring of long-lived siblings: a comparison with Danish national cancer registry data.
(Ann Epidemiol, 2015-08)
PURPOSE: Familial clustering of longevity is well documented and includes both genetic
and other familial factors, but the specific underlying mechanisms are largely unknown.
We examined whether low incidence of specific ...
Increased effect of the ApoE gene on survival at advanced age in healthy and long-lived Danes: two nationwide cohort studies.
(Aging Cell, 2010-12)
Studies of Nordic twins suggest an increased genetic influence on mortality with age.
Contrary to this, the heterogeneity hypothesis predicts that the mortality of individuals
carrying a 'frail' or 'risky' genotype in a ...
A meta-analysis of four genome-wide association studies of survival to age 90 years or older: the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium.
(J Gerontol A Biol Sci Med Sci, 2010-05)
BACKGROUND: Genome-wide association studies (GWAS) may yield insights into longevity.
METHODS: We performed a meta-analysis of GWAS in Caucasians from four prospective
cohort studies: the Age, Gene/Environment Susceptibi...
Birth cohort differences in the prevalence of longevity-associated variants in APOE and FOXO3A in Danish long-lived individuals.
(Exp Gerontol, 2014-09)
Gene variants found to associate with human longevity in one population rarely replicate
in other populations. The lack of consistent findings may partly be explained by genetic
heterogeneity among long-lived individuals ...
Cross-national comparison of sex differences in health and mortality in Denmark, Japan and the US.
(Eur J Epidemiol, 2010-07)
The present study aims to compare the direction and magnitude of sex differences in
mortality and major health dimensions across Denmark, Japan and the US. The Human
Mortality Database was used to examine sex differences ...
Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity.
(Age (Dordr), 2013-04)
In this study, we investigated 102 single-nucleotide polymorphisms (SNPs) covering
the common genetic variation in 16 genes recurrently regarded as candidates for human
longevity: APOE; ACE; CETP; HFE; IL6; IL6R; MTHFR; ...
Changes in hospitalisation and surgical procedures among the oldest-old: a follow-up study of the entire Danish 1895 and 1905 cohorts from ages 85 to 99 years.
(Age Ageing, 2013-07)
OBJECTIVE: to examine whether the Danish 1905 cohort members had more active hospital
treatment than the 1895 cohort members from ages 85 to 99 years and whether it results
in higher in-hospital and post-operative mortality. ...