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The miR-184 binding-site rs8126 T>C polymorphism in TNFAIP2 is associated with risk of gastric cancer. 

Xu, Yu; Ma, Hongxia; Yu, Hongping; Liu, Zhensheng; Wang, Li-E; Tan, Dongfeng; Muddasani, Ramya; ... (11 authors) (PloS one, 2013-01)
TNFAIP2 is a crucial gene involved in apoptosis. Single nucleotide polymorphisms (SNPs) in its miRNA binding sites could modulate functions of the miRNA-target genes and thus risk of cancers. In this study, we investigated ...
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A pri-miR-218 variant and risk of cervical carcinoma in Chinese women. 

Shi, Ting-Yan; Chen, Xiao-Jun; Zhu, Mei-Ling; Wang, Meng-Yun; He, Jing; Yu, Ke-Da; Shao, Zhi-Ming; ... (12 authors) (BMC cancer, 2013-01-15)
BACKGROUND: MicroRNA (miRNA)-related single nucleotide polymorphisms (SNPs) may compromise miRNA binding affinity and modify mRNA expression levels of the target genes, thus leading to cancer susceptibility. However, few ...
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Polymorphisms of nucleotide excision repair genes predict melanoma survival. 

Li, Chunying; Yin, Ming; Wang, Li-E; Amos, Christopher I; Zhu, Dakai; Lee, Jeffrey E; Gershenwald, Jeffrey E; ... (9 authors) (The Journal of investigative dermatology, 2013-07)
Melanoma is the most highly malignant skin cancer, and nucleotide excision repair (NER) is involved in melanoma susceptibility. In this analysis of 1,042 melanoma patients, we evaluated whether genetic variants of NER genes ...
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Phase II trial of upfront bevacizumab and temozolomide for unresectable or multifocal glioblastoma. 

Lou, Emil; Peters, Katherine B; Sumrall, Ashley L; Desjardins, Annick; Reardon, David A; Lipp, Eric S; Herndon, James E; ... (12 authors) (Cancer Med, 2013-04)
Patients with unresectable glioblastomas have a poor prognosis, with median survival of 6-10 months. We conducted a phase II trial of upfront 5-day temozolomide (TMZ) and bevacizumab (BV) in patients with newly diagnosed ...
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Hazard-rate analysis and patterns of recurrence in early stage melanoma: moving towards a rationally designed surveillance strategy. 

Salama, April KS; de Rosa, Nicole; Scheri, Randall P; Pruitt, Scott K; Herndon, James E; Marcello, Jennifer; Tyler, Douglas S; ... (8 authors) (PLoS One, 2013)
BACKGROUND: While curable at early stages, few treatment options exist for advanced melanoma. Currently, no consensus exists regarding the optimal surveillance strategy for patients after resection. The objectives of this ...
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Potentially functional polymorphisms in the CASP7 gene contribute to gastric adenocarcinoma susceptibility in an eastern Chinese population. 

Wang, Meng-Yun; Zhu, Mei-Ling; He, Jing; Shi, Ting-Yan; Li, Qiao-Xin; Wang, Ya-Nong; Li, Jin; ... (14 authors) (PloS one, 2013-01)
BACKGROUND: Caspase 7 (CASP7) is an important regulator and executioner in the apoptosis pathway and plays a crucial role in cancer development and progression. However, few studies have evaluated associations between functional ...
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Association of tumor necrosis factor-alpha promoter variants with risk of HPV-associated oral squamous cell carcinoma. 

Jin, Lei; Sturgis, Erich M; Zhang, Yang; Huang, Zhigang; Song, Xicheng; Li, Chao; Wei, Qingyi; ... (8 authors) (Molecular cancer, 2013-07-19)
Tumor necrosis factor alpha (TNF-α) plays an important role in inflammation, immunity, and defense against infection and clearance of human papillomavirus (HPV). Thus, genetic variants may modulate individual susceptibility ...
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TGFβ1 Polymorphisms Predict Distant Metastasis-Free Survival in Patients with Inoperable Non-Small-Cell Lung Cancer after Definitive Radiotherapy. 

Yuan, Xianglin; Wei, Qingyi; Komaki, Ritsuko; Liu, Zhensheng; Yang, Ju; Tucker, Susan L; Xu, Ting; ... (11 authors) (PloS one, 2013-01)
Transforming growth factor (TGF) -β1 signaling is involved in cancer-cell metastasis. We investigated whether single nucleotide polymorphisms (SNPs) at TGFβ1 were associated with overall survival (OS) and distant metastasis-free ...
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Joint effect of multiple common SNPs predicts melanoma susceptibility. 

Fang, Shenying; Han, Jiali; Zhang, Mingfeng; Wang, Li-e; Wei, Qingyi; Amos, Christopher I; Lee, Jeffrey E (PloS one, 2013-01)
Single genetic variants discovered so far have been only weakly associated with melanoma. This study aims to use multiple single nucleotide polymorphisms (SNPs) jointly to obtain a larger genetic effect and to improve the ...
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MicroRNA variants increase the risk of HPV-associated squamous cell carcinoma of the oropharynx in never smokers. 

Song, Xicheng; Sturgis, Erich M; Liu, Jun; Jin, Lei; Wang, Zhongqiu; Zhang, Caiyun; Wei, Qingyi; ... (8 authors) (PloS one, 2013-01)
Both microRNAs and human papillomavirus (HPV) infection play an important role in the development and progression of oral squamous cell carcinoma (OSCC). In addition, microRNAs affect all facets of the immune/inflammation ...
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AuthorWei, Qingyi (8)Liu, Zhensheng (4)Wang, Li-E (4)Sturgis, Erich M (3)Ajani, Jaffer A (2)Amos, Christopher I (2)He, Jing (2)Herndon, James E (2)Jin, Lei (2)Lee, Jeffrey E (2)... View MoreDate Issued
2013 (13)
TypeJournal article (13)Subject
Female (13)
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Male (12)Adult (11)Polymorphism, Single Nucleotide (10)Aged (9)Aged, 80 and over (6)Genetic Predisposition to Disease (6)Young Adult (6)... View MoreAffiliation of Duke Author(s)
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Medicine, Medical Oncology (13)
School of Medicine (13)Population Health Sciences (10)Staff (4)... View More
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