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Now showing items 1-10 of 17
Polyclonal B cell differentiation and loss of gastrointestinal tract germinal centers in the earliest stages of HIV-1 infection.
(PLoS Med, 2009-07-07)
BACKGROUND: The antibody response to HIV-1 does not appear in the plasma until approximately
2-5 weeks after transmission, and neutralizing antibodies to autologous HIV-1 generally
do not become detectable until 12 weeks ...
Metronomic chemotherapy with daily, oral etoposide plus bevacizumab for recurrent malignant glioma: a phase II study.
(Br J Cancer, 2009-12-15)
BACKGROUND: We evaluated bevacizumab with metronomic etoposide among recurrent malignant
glioma patients in a phase 2, open-label trial. METHODS: A total of 59 patients, including
27 with glioblastoma (GBM) and 32 with grade ...
Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis.
(PLoS Genet, 2009-01)
Neuropeptide Y (NPY) is a strong candidate gene for coronary artery disease (CAD).
We have previously identified genetic linkage to familial CAD in the genomic region
of NPY. We performed follow-up genetic, biostatistical, ...
A new instrument for measuring anticoagulation-related quality of life: development and preliminary validation.
(Health Qual Life Outcomes, 2004-05-06)
BACKGROUND: Anticoagulation can reduce quality of life, and different models of anticoagulation
management might have different impacts on satisfaction with this component of medical
care. Yet, to our knowledge, there are ...
Oxygen for relief of dyspnoea in mildly- or non-hypoxaemic patients with cancer: a systematic review and meta-analysis.
(Br J Cancer, 2008-01-29)
The aim of this study was to determine the efficacy of palliative oxygen for relief
of dyspnoea in cancer patients. MEDLINE and EMBASE were searched for randomised controlled
trials, comparing oxygen and medical air in cancer ...
Comorbidity, age, race and stage at diagnosis in colorectal cancer: a retrospective, parallel analysis of two health systems.
(BMC Cancer, 2008-11-25)
BACKGROUND: Stage at diagnosis plays a significant role in colorectal cancer (CRC)
survival. Understanding which factors contribute to a more advanced stage at diagnosis
is vital to improving overall survival. Comorbidity, ...
Meningococcemia in a patient coinfected with hepatitis C virus and HIV.
(Emerg Infect Dis, 2000-11)
We describe the first reported case of meningococcemia in a patient coinfected with
hepatitis C virus and HIV. Hypocomplementemia secondary to hepatic dysfunction may
have enhanced the patient's susceptibility to meningococcal ...
Treatment with Imatinib in NSCLC is associated with decrease of phosphorylated PDGFR-beta and VEGF expression, decrease in interstitial fluid pressure and improvement of oxygenation.
(Br J Cancer, 2006-10-23)
Elevated intratumoral interstitial fluid pressure (IFP) and tumour hypoxia are independent
predictive factors for poor survival and poor treatment response in cancer patients.
However, the relationship between IFP and tumour ...
Gene expression signatures that predict radiation exposure in mice and humans.
(PLoS Med, 2007-04)
BACKGROUND: The capacity to assess environmental inputs to biological phenotypes is
limited by methods that can accurately and quantitatively measure these contributions.
One such example can be seen in the context of exposure ...
Gene expression signatures of radiation response are specific, durable and accurate in mice and humans.
(PLoS One, 2008-04-02)
BACKGROUND: Previous work has demonstrated the potential for peripheral blood (PB)
gene expression profiling for the detection of disease or environmental exposures.
METHODS AND FINDINGS: We have sought to determine the ...