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Trade-offs in the effects of the apolipoprotein E polymorphism on risks of diseases of the heart, cancer, and neurodegenerative disorders: insights on mechanisms from the Long Life Family Study.

Arbeev, Konstantin; Culminskaya, IV; Kulminski, Alexander; Province, MA; Stallard, Eric; Ukraintseva, Svetlana; Yashin, Anatoli I (Rejuvenation Res, 2015-04)

The lack of evolutionary established mechanisms linking genes to age-related traits makes the problem of genetic susceptibility to health span inherently complex. One complicating factor is genetic trade-off. Here we focused ...