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Now showing items 1-10 of 21
Polyclonal B cell differentiation and loss of gastrointestinal tract germinal centers in the earliest stages of HIV-1 infection.
(PLoS Med, 2009-07-07)
BACKGROUND: The antibody response to HIV-1 does not appear in the plasma until approximately
2-5 weeks after transmission, and neutralizing antibodies to autologous HIV-1 generally
do not become detectable until 12 weeks ...
Metronomic chemotherapy with daily, oral etoposide plus bevacizumab for recurrent malignant glioma: a phase II study.
(Br J Cancer, 2009-12-15)
BACKGROUND: We evaluated bevacizumab with metronomic etoposide among recurrent malignant
glioma patients in a phase 2, open-label trial. METHODS: A total of 59 patients, including
27 with glioblastoma (GBM) and 32 with grade ...
Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis.
(PLoS Genet, 2009-01)
Neuropeptide Y (NPY) is a strong candidate gene for coronary artery disease (CAD).
We have previously identified genetic linkage to familial CAD in the genomic region
of NPY. We performed follow-up genetic, biostatistical, ...
Reported lifetime aberrant drug-taking behaviors are predictive of current substance use and mental health problems in primary care patients.
(Pain Med, 2008-11)
BACKGROUND: The aim of this report is to determine the frequency of aberrant drug
behaviors and their relationship to substance abuse disorders in a large primary sample
of patients receiving opioids for chronic pain. METHODS: ...
The design of an observational study of hypertension management, adherence and pressure control in Blood Pressure Success Zone Program participants.
(Int J Clin Pract, 2008-09)
AIMS: The Blood Pressure Success Zone (BPSZ) Program, a nationwide initiative, provides
education in addition to a complimentary trial of one of three antihypertensive medications.
The BPSZ Longitudinal Observational Study ...
A new instrument for measuring anticoagulation-related quality of life: development and preliminary validation.
(Health Qual Life Outcomes, 2004-05-06)
BACKGROUND: Anticoagulation can reduce quality of life, and different models of anticoagulation
management might have different impacts on satisfaction with this component of medical
care. Yet, to our knowledge, there are ...
Amino acid racemization reveals differential protein turnover in osteoarthritic articular and meniscal cartilages.
(Arthritis Res Ther, 2009)
INTRODUCTION: Certain amino acids within proteins have been reported to change from
the L form to the D form over time. This process is known as racemization and is most
likely to occur in long-lived low-turnover tissues ...
Patient detection of a drug dispensing error by use of physician-provided drug samples.
(Pharmacotherapy, 2002-12)
Comorbidity, age, race and stage at diagnosis in colorectal cancer: a retrospective, parallel analysis of two health systems.
(BMC Cancer, 2008-11-25)
BACKGROUND: Stage at diagnosis plays a significant role in colorectal cancer (CRC)
survival. Understanding which factors contribute to a more advanced stage at diagnosis
is vital to improving overall survival. Comorbidity, ...
Post-translational aging of proteins in osteoarthritic cartilage and synovial fluid as measured by isomerized aspartate.
(Arthritis Res Ther, 2009)
INTRODUCTION: Aging proteins undergo non-enzymatic post-translational modification,
including isomerization and racemization. We hypothesized that cartilage with many
long-lived components could accumulate non-enzymatically ...