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Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis.
(PLoS Genet, 2009-01)
Neuropeptide Y (NPY) is a strong candidate gene for coronary artery disease (CAD).
We have previously identified genetic linkage to familial CAD in the genomic region
of NPY. We performed follow-up genetic, biostatistical, ...
beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1.
(Mol Cell Biol, 2004-10)
beta-arrestin-1 is an adaptor protein that mediates agonist-dependent internalization
and desensitization of G-protein-coupled receptors (GPCRs) and also participates in
the process of heterologous desensitization between ...
beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi.
(Proc Natl Acad Sci U S A, 2003-02-04)
Phosphorylation of the beta(2) adrenoreceptor (beta(2)AR) by cAMP-activated protein
kinase A (PKA) switches its predominant coupling from stimulatory guanine nucleotide
regulatory protein (G(s)) to inhibitory guanine nucleotide ...
Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity.
(Proc Natl Acad Sci U S A, 2000-02-01)
Recently, we identified a GTPase-activating protein for the ADP ribosylation factor
family of small GTP-binding proteins that we call GIT1. This protein initially was
identified as an interacting partner for the G protein-coupled ...
Treatment with Imatinib in NSCLC is associated with decrease of phosphorylated PDGFR-beta and VEGF expression, decrease in interstitial fluid pressure and improvement of oxygenation.
(Br J Cancer, 2006-10-23)
Elevated intratumoral interstitial fluid pressure (IFP) and tumour hypoxia are independent
predictive factors for poor survival and poor treatment response in cancer patients.
However, the relationship between IFP and tumour ...
Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds.
(Proc Natl Acad Sci U S A, 2001-02-27)
Using both confocal immunofluorescence microscopy and biochemical approaches, we have
examined the role of beta-arrestins in the activation and targeting of extracellular
signal-regulated kinase 2 (ERK2) following stimulation ...
Augmentation of cardiac contractility mediated by the human beta(3)-adrenergic receptor overexpressed in the hearts of transgenic mice.
(Circulation, 2001-11-13)
BACKGROUND: Stimulation of beta(1)- and beta(2)-adrenergic receptors (ARs) in the
heart results in positive inotropy. In contrast, it has been reported that the beta(3)AR
is also expressed in the human heart and that its ...
Gene expression signatures that predict radiation exposure in mice and humans.
(PLoS Med, 2007-04)
BACKGROUND: The capacity to assess environmental inputs to biological phenotypes is
limited by methods that can accurately and quantitatively measure these contributions.
One such example can be seen in the context of exposure ...
Gene expression signatures of radiation response are specific, durable and accurate in mice and humans.
(PLoS One, 2008-04-02)
BACKGROUND: Previous work has demonstrated the potential for peripheral blood (PB)
gene expression profiling for the detection of disease or environmental exposures.
METHODS AND FINDINGS: We have sought to determine the ...
beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice.
(J Clin Invest, 2009-05)
Nicotinic acid is one of the most effective agents for both lowering triglycerides
and raising HDL. However, the side effect of cutaneous flushing severely limits patient
compliance. As nicotinic acid stimulates the GPCR ...