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Genome-wide association study of acute kidney injury after coronary bypass graft surgery identifies susceptibility loci.
(Kidney Int, 2015-10)
Acute kidney injury (AKI) is a common, serious complication of cardiac surgery. Since
prior studies have supported a genetic basis for postoperative AKI, we conducted a
genome-wide association study (GWAS) for AKI following ...
Provider specialty and atrial fibrillation treatment strategies in United States community practice: findings from the ORBIT-AF registry.
(J Am Heart Assoc, 2013-07-18)
BACKGROUND: The prevalence of atrial fibrillation (AF) continues to increase; however,
there are limited data describing the division of care among practitioners in the
community and whether care differs depending on provider ...
Hypertension and obesity as cardiovascular risk factors among HIV seropositive patients in Western Kenya.
(PLoS One, 2011)
BACKGROUND: There is increased risk of cardiovascular disease among HIV seropositive
individuals. The prevalence of HIV is highest in sub-Saharan Africa; however, HIV-related
cardiovascular risk research is largely derived ...
A novel inflammatory biomarker, GlycA, associates with disease activity in rheumatoid arthritis and cardio-metabolic risk in BMI-matched controls.
(Arthritis Res Ther, 2016-04-12)
BACKGROUND: RA and CVD both have inflammation as part of the underlying biology. Our
objective was to explore the relationships of GlycA, a measure of glycosylated acute
phase proteins, with inflammation and cardiometabolic ...
Catheter Ablation of Atrial Fibrillation in U.S. Community Practice--Results From Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF).
(J Am Heart Assoc, 2015-05-21)
BACKGROUND: The characteristics of patients undergoing atrial fibrillation (AF) ablation
and subsequent outcomes in community practice are not well described. METHODS AND
RESULTS: Using the Outcomes Registry for Better Informed ...
Simplified Predictive Instrument to Rule Out Acute Coronary Syndromes in a High-Risk Population.
(J Am Heart Assoc, 2015-12-14)
BACKGROUND: It is unclear whether diagnostic protocols based on cardiac markers to
identify low-risk chest pain patients suitable for early release from the emergency
department can be applied to patients older than 65 years ...
Blood pressure level impacts risk of death among HIV seropositive adults in Kenya: a retrospective analysis of electronic health records.
(BMC Infect Dis, 2014-05-22)
BACKGROUND: Mortality among people with human immunodeficiency virus (HIV) infection
is increasingly due to non-communicable causes. This has been observed mostly in developed
countries and the routine care of HIV infected ...
Gene Expression Profiles Link Respiratory Viral Infection, Platelet Response to Aspirin, and Acute Myocardial Infarction.
(PLoS One, 2015)
BACKGROUND: Influenza infection is associated with myocardial infarction (MI), suggesting
that respiratory viral infection may induce biologic pathways that contribute to MI.
We tested the hypotheses that 1) a validated ...
Long-term outcome and impact of surgery on adults with coronary arteries originating from the opposite coronary cusp.
(Circulation, 2011-01-18)
BACKGROUND: An anomalous coronary artery from the opposite sinus of Valsalva may increase
sudden death risk in children and young adults, and surgical intervention is often
recommended. The impact of this lesion when recognized ...
Preoperative CYP2D6 metabolism-dependent β-blocker use and mortality after coronary artery bypass grafting surgery.
(J Thorac Cardiovasc Surg, 2014-04)
OBJECTIVE: Recently, the role of β-blockers (BBs) in reducing perioperative mortality
has been challenged. The conflicting results might have resulted from the extent of
BB metabolism by the cytochrome P-450 (CYP2D6) isoenzyme. ...