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The miR-184 binding-site rs8126 T>C polymorphism in TNFAIP2 is associated with risk of gastric cancer.
(PloS one, 2013-01)
TNFAIP2 is a crucial gene involved in apoptosis. Single nucleotide polymorphisms (SNPs)
in its miRNA binding sites could modulate functions of the miRNA-target genes and
thus risk of cancers. In this study, we investigated ...
Association between novel PLCE1 variants identified in published esophageal cancer genome-wide association studies and risk of squamous cell carcinoma of the head and neck.
(BMC cancer, 2011-06-20)
Phospholipase C epsilon 1 (PLCE1) (an effector of Ras) belonging to the phospholipase
family plays crucial roles in carcinogenesis and progression of several cancers, including
squamous cell carcinoma of the head and neck ...
Polymorphisms at the microRNA binding-site of the stem cell marker gene CD133 modify susceptibility to and survival of gastric cancer.
(Mol Carcinog, 2015-06)
CD133 is one of the most common stem cell markers, and functional single nucleotide
polymorphisms (SNPs) of CD133 may modulate its gene functions and thus cancer risk
and patient survival. We hypothesized that potentially ...
Polymorphisms in the kinesin-like factor 1 B gene and risk of epithelial ovarian cancer in Eastern Chinese women.
(Tumour Biol, 2015-09)
The kinesin-like factor 1 B (KIF1B) gene plays an important role in the process of
apoptosis and the transformation and progression of malignant cells. Genetic variations
in KIF1B may contribute to risk of epithelial ovarian ...
Genetic variants in the TEP1 gene are associated with prostate cancer risk and recurrence.
(Prostate Cancer Prostatic Dis, 2015-12)
BACKGROUND: Telomere-related genes play an important role in carcinogenesis and progression
of prostate cancer (PCa). It is not fully understood whether genetic variations in
telomere-related genes are associated with development ...
Polymorphisms in the AKT1 and AKT2 genes and oesophageal squamous cell carcinoma risk in an Eastern Chinese population.
(Journal of cellular and molecular medicine, 2016-04)
Ethnic Han Chinese are at high risk of developing oesophageal squamous cell carcinoma
(ESCC). Aberrant activation of the AKT signalling pathway is involved in many cancers,
including ESCC. Some single nucleotide polymorphisms ...
On the interplay of telomeres, nevi and the risk of melanoma.
(PloS one, 2012-01)
The relationship between telomeres, nevi and melanoma is complex. Shorter telomeres
have been found to be associated with many cancers and with number of nevi, a known
risk factor for melanoma. However, shorter telomeres ...
Genetic variant rs4072037 of MUC1 and gastric cancer risk in an Eastern Chinese population.
(Oncotarget, 2016-03)
Published data on the association between the MUC1 rs4072037A > G polymorphism and
gastric cancer (GCa) risk were inconclusive. To derive a more precise estimation of
the association, we conducted a large GCa study of 1,124 ...
Genetic variant of PRKAA1 and gastric cancer risk in an eastern Chinese population.
(Oncotarget, 2015-12)
Published data on the association between PRKAA1 rs13361707 T > C polymorphism and
gastric cancer (GCa) susceptibility were inconclusive. To derive a more precise estimation
of the association, we conducted a large-scale ...
A genetic variant in the APE1/Ref-1 gene promoter -141T/G may modulate risk of glioblastoma in a Chinese Han population.
(BMC cancer, 2011-01)
BACKGROUND: The human apurinic/apyrimidinic endonuclease 1/Redox effector factor-1
(APE1/Ref-1) is implicated in tumor development and progression. Recently, the APE1/Ref-1
promoter -141T/G variant (rs1760944) has been reported ...