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Polymorphisms at the microRNA binding-site of the stem cell marker gene CD133 modify susceptibility to and survival of gastric cancer. 

Wang, Qiming; Liu, Hongliang; Xiong, Huihua; Liu, Zhensheng; Wang, Li-E; Qian, Ji; Muddasani, Ramya; ... (11 authors) (Mol Carcinog, 2015-06)
CD133 is one of the most common stem cell markers, and functional single nucleotide polymorphisms (SNPs) of CD133 may modulate its gene functions and thus cancer risk and patient survival. We hypothesized that potentially ...
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Polymorphisms in the kinesin-like factor 1 B gene and risk of epithelial ovarian cancer in Eastern Chinese women. 

Shi, Ting-Yan; Jiang, Zhi; Jiang, Rong; Yin, Sheng; Wang, Meng-Yun; Yu, Ke-Da; Shao, Zhi-Ming; ... (10 authors) (Tumour Biol, 2015-09)
The kinesin-like factor 1 B (KIF1B) gene plays an important role in the process of apoptosis and the transformation and progression of malignant cells. Genetic variations in KIF1B may contribute to risk of epithelial ovarian ...
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Genetic variants in the TEP1 gene are associated with prostate cancer risk and recurrence. 

Gu, C; Li, Q; Zhu, Y; Qu, Y; Zhang, G; Wang, M; Yang, Y; ... (11 authors) (Prostate Cancer Prostatic Dis, 2015-12)
BACKGROUND: Telomere-related genes play an important role in carcinogenesis and progression of prostate cancer (PCa). It is not fully understood whether genetic variations in telomere-related genes are associated with development ...
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The miR-184 binding-site rs8126 T>C polymorphism in TNFAIP2 is associated with risk of gastric cancer. 

Xu, Yu; Ma, Hongxia; Yu, Hongping; Liu, Zhensheng; Wang, Li-E; Tan, Dongfeng; Muddasani, Ramya; ... (11 authors) (PloS one, 2013-01)
TNFAIP2 is a crucial gene involved in apoptosis. Single nucleotide polymorphisms (SNPs) in its miRNA binding sites could modulate functions of the miRNA-target genes and thus risk of cancers. In this study, we investigated ...
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Association between novel PLCE1 variants identified in published esophageal cancer genome-wide association studies and risk of squamous cell carcinoma of the head and neck. 

Ma, Hongxia; Wang, Li-E; Liu, Zhensheng; Sturgis, Erich M; Wei, Qingyi (BMC cancer, 2011-06-20)
Phospholipase C epsilon 1 (PLCE1) (an effector of Ras) belonging to the phospholipase family plays crucial roles in carcinogenesis and progression of several cancers, including squamous cell carcinoma of the head and neck ...
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Genetic variant of PRKAA1 and gastric cancer risk in an eastern Chinese population. 

Qiu, Li-Xin; He, Jing; Cheng, Lei; Zhou, Fei; Wang, Meng-Yun; Sun, Meng-Hong; Zhou, Xiao-Yan; ... (15 authors) (Oncotarget, 2015-12)
Published data on the association between PRKAA1 rs13361707 T > C polymorphism and gastric cancer (GCa) susceptibility were inconclusive. To derive a more precise estimation of the association, we conducted a large-scale ...
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Polymorphisms in the ERCC5 gene and risk of esophageal squamous cell carcinoma (ESCC) in Eastern Chinese populations. 

Zhu, Mei-Ling; Shi, Ting-Yan; Hu, Hai-Chuan; He, Jing; Wang, Mengyun; Jin, Li; Yang, Ya-Jun; ... (15 authors) (PloS one, 2012-01)
BACKGROUND: Excision repair cross complementing group 5 (ERCC5 or XPG) plays an important role in regulating DNA excision repair; its functional single nucleotide polymorphisms (SNPs) may alter DNA repair capacity and thus ...
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A genetic variant in the APE1/Ref-1 gene promoter -141T/G may modulate risk of glioblastoma in a Chinese Han population. 

Zhou, Keke; Hu, Dezhi; Lu, Juan; Fan, Weiwei; Liu, Hongliang; Chen, Hongyan; Chen, Gong; ... (12 authors) (BMC cancer, 2011-01)
BACKGROUND: The human apurinic/apyrimidinic endonuclease 1/Redox effector factor-1 (APE1/Ref-1) is implicated in tumor development and progression. Recently, the APE1/Ref-1 promoter -141T/G variant (rs1760944) has been reported ...
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On the interplay of telomeres, nevi and the risk of melanoma. 

Bodelon, Clara; Pfeiffer, Ruth M; Bollati, Valentina; Debbache, Julien; Calista, Donato; Ghiorzo, Paola; Fargnoli, Maria Concetta; ... (22 authors) (PloS one, 2012-01)
The relationship between telomeres, nevi and melanoma is complex. Shorter telomeres have been found to be associated with many cancers and with number of nevi, a known risk factor for melanoma. However, shorter telomeres ...
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Associations of potentially functional variants in IL-6, JAKs and STAT3 with gastric cancer risk in an eastern Chinese population. 

Zhou, Fei; Cheng, Lei; Qiu, Li-Xin; Wang, Meng-Yun; Li, Jin; Sun, Meng-Hong; Yang, Ya-Jun; ... (11 authors) (Oncotarget, 2016-05)
The interleukin-6 (IL-6)/JAK/STAT3 signaling pathway plays a central role in inflammation-mediated cancers, including gastric cancer (GCa). We evaluated associations between 10 potentially functional single nucleotide ...
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AuthorJin, Li (10)Wei, Qingyi (10)Sun, Meng-Hong (8)Wang, Jiu-Cun (8)Yang, Ya-Jun (8)He, Jing (7)Wang, Meng-Yun (7)Wei, Qing-Yi (7)Li, Jin (6)Wang, Ya-Nong (6)... View MoreDate Issued2016 (6)2015 (4)2012 (3)2011 (2)2013 (1)2014 (1)2017 (1)TypeJournal article (18)SubjectHumans (18)
Middle Aged (18)
Polymorphism, Single Nucleotide (18)
Risk Factors (18)
Female (16)Genetic Predisposition to Disease (16)Male (16)Case-Control Studies (14)Aged (12)Asian Continental Ancestry Group (12)... View MoreAffiliation of Duke Author(s)Clinical Science Departments (18)Duke (18)Duke Cancer Institute (18)
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Medicine (18)
Medicine, Medical Oncology (18)
School of Medicine (18)
Basic Science Departments (15)Population Health Sciences (15)Staff (2)
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