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Sinus Node Dysfunction Is Associated With Higher Symptom Burden and Increased Comorbid Illness: Results From the ORBIT-AF Registry.
(Clin Cardiol, 2016-02)
BACKGROUND: Patients with sinus node dysfunction (SND) have increased risk of atrial
tachyarrhythmias, including atrial fibrillation (AF). To date, treatment patterns
and outcomes of patients with SND and AF have not been ...
Genome-wide association study of acute kidney injury after coronary bypass graft surgery identifies susceptibility loci.
(Kidney Int, 2015-10)
Acute kidney injury (AKI) is a common, serious complication of cardiac surgery. Since
prior studies have supported a genetic basis for postoperative AKI, we conducted a
genome-wide association study (GWAS) for AKI following ...
Outcomes According to Cardiac Catheterization Referral and Clopidogrel Use Among Medicare Patients With Non-ST-Segment Elevation Myocardial Infarction Discharged Without In-hospital Revascularization.
(J Am Heart Assoc, 2016-03-14)
BACKGROUND: While use of P2Y12 receptor inhibitor is recommended by guidelines, few
studies have examined its effectiveness among older non-ST-segment elevation myocardial
infarction patients who did not undergo coronary ...
Renal systems biology of patients with systemic inflammatory response syndrome.
(Kidney Int, 2015-10)
A systems biology approach was used to comprehensively examine the impact of renal
disease and hemodialysis (HD) on patient response during critical illness. To achieve
this, we examined the metabolome, proteome, ...
Delays in appropriate antibiotic therapy for gram-negative bloodstream infections: a multicenter, community hospital study.
(PLoS One, 2013)
BACKGROUND: Gram-negative bacterial bloodstream infection (BSI) is a serious condition
with estimated 30% mortality. Clinical outcomes for patients with severe infections
improve when antibiotics are appropriately chosen ...
Bacteremic disseminated tuberculosis in sub-saharan Africa: a prospective cohort study.
(Clin Infect Dis, 2012-07)
BACKGROUND: Disseminated tuberculosis is a major health problem in countries where
generalized human immunodeficiency virus (HIV) infection epidemics coincide with high
tuberculosis incidence rates; data are limited on patient ...
Early adoption of dabigatran and its dosing in US patients with atrial fibrillation: results from the outcomes registry for better informed treatment of atrial fibrillation.
(J Am Heart Assoc, 2013-11-25)
BACKGROUND: Dabigatran is a novel oral anticoagulant approved for thromboprophylaxis
in atrial fibrillation. Adoption patterns of this new agent in community practice
are unknown. METHODS AND RESULTS: We studied patterns ...
How Reliable are Patient-Reported Rehospitalizations? Implications for the Design of Future Practical Clinical Studies.
(J Am Heart Assoc, 2016-01-25)
BACKGROUND: Longitudinal clinical investigations often rely on patient reports to
screen for postdischarge adverse outcomes events, yet few studies have examined the
accuracy of such patient reports. METHODS AND RESULTS: ...
Relief and Recurrence of Congestion During and After Hospitalization for Acute Heart Failure: Insights From Diuretic Optimization Strategy Evaluation in Acute Decompensated Heart Failure (DOSE-AHF) and Cardiorenal Rescue Study in Acute Decompensated Heart Failure (CARESS-HF).
(Circ Heart Fail, 2015-07)
BACKGROUND: Congestion is the most frequent cause for hospitalization in acute decompensated
heart failure. Although decongestion is a major goal of acute therapy, it is unclear
how the clinical components of congestion ...
Increased Heart Rate Is Associated With Higher Mortality in Patients With Atrial Fibrillation (AF): Results From the Outcomes Registry for Better Informed Treatment of AF (ORBIT-AF).
(J Am Heart Assoc, 2015-09-14)
BACKGROUND: Most patients with atrial fibrillation (AF) require rate control; however,
the optimal target heart rate remains under debate. We aimed to assess rate control
and subsequent outcomes among patients with permanent ...