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Renal systems biology of patients with systemic inflammatory response syndrome.
(Kidney Int, 2015-10)
A systems biology approach was used to comprehensively examine the impact of renal
disease and hemodialysis (HD) on patient response during critical illness. To achieve
this, we examined the metabolome, proteome, ...
Relief and Recurrence of Congestion During and After Hospitalization for Acute Heart Failure: Insights From Diuretic Optimization Strategy Evaluation in Acute Decompensated Heart Failure (DOSE-AHF) and Cardiorenal Rescue Study in Acute Decompensated Heart Failure (CARESS-HF).
(Circ Heart Fail, 2015-07)
BACKGROUND: Congestion is the most frequent cause for hospitalization in acute decompensated
heart failure. Although decongestion is a major goal of acute therapy, it is unclear
how the clinical components of congestion ...
Association Between Comorbidities and Outcomes in Heart Failure Patients With and Without an Implantable Cardioverter-Defibrillator for Primary Prevention.
(J Am Heart Assoc, 2015-08-06)
BACKGROUND: Implantable cardioverter-defibrillator (ICD) therapy is associated with
improved outcomes in patients with heart failure (HF), but whether this association
holds among older patients with multiple comorbid illnesses ...
Sinus Node Dysfunction Is Associated With Higher Symptom Burden and Increased Comorbid Illness: Results From the ORBIT-AF Registry.
(Clin Cardiol, 2016-02)
BACKGROUND: Patients with sinus node dysfunction (SND) have increased risk of atrial
tachyarrhythmias, including atrial fibrillation (AF). To date, treatment patterns
and outcomes of patients with SND and AF have not been ...
Increased Heart Rate Is Associated With Higher Mortality in Patients With Atrial Fibrillation (AF): Results From the Outcomes Registry for Better Informed Treatment of AF (ORBIT-AF).
(J Am Heart Assoc, 2015-09-14)
BACKGROUND: Most patients with atrial fibrillation (AF) require rate control; however,
the optimal target heart rate remains under debate. We aimed to assess rate control
and subsequent outcomes among patients with permanent ...
Risk Factors for Heart Failure in Patients With Chronic Kidney Disease: The CRIC (Chronic Renal Insufficiency Cohort) Study.
(Journal of the American Heart Association, 2017-05-17)
BACKGROUND:Heart failure is common in patients with chronic kidney disease. We studied
risk factors for incident heart failure among 3557 participants in the CRIC (Chronic
Renal Insufficiency Cohort) Study. METHODS ...
Genome-wide association study of acute kidney injury after coronary bypass graft surgery identifies susceptibility loci.
(Kidney Int, 2015-10)
Acute kidney injury (AKI) is a common, serious complication of cardiac surgery. Since
prior studies have supported a genetic basis for postoperative AKI, we conducted a
genome-wide association study (GWAS) for AKI following ...
Early adoption of dabigatran and its dosing in US patients with atrial fibrillation: results from the outcomes registry for better informed treatment of atrial fibrillation.
(J Am Heart Assoc, 2013-11-25)
BACKGROUND: Dabigatran is a novel oral anticoagulant approved for thromboprophylaxis
in atrial fibrillation. Adoption patterns of this new agent in community practice
are unknown. METHODS AND RESULTS: We studied patterns ...
Delays in appropriate antibiotic therapy for gram-negative bloodstream infections: a multicenter, community hospital study.
(PLoS One, 2013)
BACKGROUND: Gram-negative bacterial bloodstream infection (BSI) is a serious condition
with estimated 30% mortality. Clinical outcomes for patients with severe infections
improve when antibiotics are appropriately chosen ...
Fibroblast growth factor 23 is not associated with and does not induce arterial calcification.
(Kidney international, 2013-06)
Elevated fibroblast growth factor 23 (FGF23) is associated with cardiovascular disease
in patients with chronic kidney disease. As a potential mediating mechanism, FGF23
induces left ventricular hypertrophy; however, its ...