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beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1.
(Mol Cell Biol, 2004-10)
beta-arrestin-1 is an adaptor protein that mediates agonist-dependent internalization
and desensitization of G-protein-coupled receptors (GPCRs) and also participates in
the process of heterologous desensitization between ...
beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi.
(Proc Natl Acad Sci U S A, 2003-02-04)
Phosphorylation of the beta(2) adrenoreceptor (beta(2)AR) by cAMP-activated protein
kinase A (PKA) switches its predominant coupling from stimulatory guanine nucleotide
regulatory protein (G(s)) to inhibitory guanine nucleotide ...
Augmentation of cardiac contractility mediated by the human beta(3)-adrenergic receptor overexpressed in the hearts of transgenic mice.
(Circulation, 2001-11-13)
BACKGROUND: Stimulation of beta(1)- and beta(2)-adrenergic receptors (ARs) in the
heart results in positive inotropy. In contrast, it has been reported that the beta(3)AR
is also expressed in the human heart and that its ...
Regulation of G protein-coupled receptor signaling by scaffold proteins.
(Circ Res, 2002-10-18)
The actions of many hormones and neurotransmitters are mediated through stimulation
of G protein-coupled receptors. A primary mechanism by which these receptors exert
effects inside the cell is by association with heterotrimeric ...
When 7 transmembrane receptors are not G protein-coupled receptors.
(J Clin Invest, 2005-11)
Classically, 7 transmembrane receptors transduce extracellular signals by coupling
to heterotrimeric G proteins, although recent in vitro studies have clearly demonstrated
that they can also signal via G protein-independent ...
Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection.
(J Clin Invest, 2007-09)
Deleterious effects on the heart from chronic stimulation of beta-adrenergic receptors
(betaARs), members of the 7 transmembrane receptor family, have classically been shown
to result from Gs-dependent adenylyl ...
Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes.
(Proc Natl Acad Sci U S A, 2001-02-13)
The goal of this study was to determine whether beta(1)-adrenergic receptor (AR) and
beta(2)-AR differ in regulating cardiomyocyte survival and apoptosis and, if so, to
explore underlying mechanisms. One potential mechanism ...
Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference.
(Proc Natl Acad Sci U S A, 2003-02-18)
Beta-arrestins bind to activated G protein-coupled receptor kinase-phosphorylated
receptors, which leads to their desensitization with respect to G proteins, internalization
via clathrin-coated pits, and signaling via a ...
Preservation of myocardial beta-adrenergic receptor signaling delays the development of heart failure after myocardial infarction.
(Proc Natl Acad Sci U S A, 2000-05-09)
When the heart fails, there is often a constellation of biochemical alterations of
the beta-adrenergic receptor (betaAR) signaling system, leading to the loss of cardiac
inotropic reserve. betaAR down-regulation and functional ...
Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2.
(Mol Cell Biol, 2006-10)
Deregulation of the Sonic hedgehog pathway has been implicated in an increasing number
of human cancers. In this pathway, the seven-transmembrane (7TM) signaling protein
Smoothened regulates cellular proliferation ...