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The human antibody response to the surface of Mycobacterium tuberculosis.
(PLoS One, 2014)
BACKGROUND: Vaccine-induced human antibodies to surface components of Haemophilus
influenzae and Streptococcus pneumonia are correlated with protection. Monoclonal
antibodies to surface components of Mycobacterium tuberculosis ...
Initiation of antiretroviral therapy in HIV-infected adults with skin complaints in northern Tanzania.
(Int J Dermatol, 2015-01)
Abnormal skin findings are identified in over 90% of human immunodeficiency virus
(HIV)-infected persons globally. A prospective cohort study of HIV-infected patients
with skin complaints commencing antiretroviral therapy ...
Clinical characteristics and 12-month outcomes of patients with valvular and non-valvular atrial fibrillation in Kenya.
(PLoS One, 2017)
BACKGROUND: Atrial fibrillation (AF) is a major contributor to the global cardiovascular
disease burden. The clinical profile and outcomes of AF patients with valvular heart
diseases in sub-Saharan Africa (SSA) have not ...
Host gene expression classifiers diagnose acute respiratory illness etiology.
(Sci Transl Med, 2016-01-20)
Acute respiratory infections caused by bacterial or viral pathogens are among the
most common reasons for seeking medical care. Despite improvements in pathogen-based
diagnostics, most patients receive inappropriate antibiotics. ...
Design of a Novel Low Cost Point of Care Tampon (POCkeT) Colposcope for Use in Resource Limited Settings.
(PLoS One, 2015)
INTRODUCTION: Current guidelines by WHO for cervical cancer screening in low- and
middle-income countries involves visual inspection with acetic acid (VIA) of the cervix,
followed by treatment during the same visit or a ...
Transcriptomic Analysis of the Host Response and Innate Resilience to Enterotoxigenic Escherichia coli Infection in Humans.
(J Infect Dis, 2016-05-01)
BACKGROUND: Enterotoxigenic Escherichia coli (ETEC) is a globally prevalent cause
of diarrhea. Though usually self-limited, it can be severe and debilitating. Little
is known about the host transcriptional response to infection. ...
Lopinavir/Ritonavir Monotherapy as Second-line Antiretroviral Treatment in Resource-Limited Settings: Week 104 Analysis of AIDS Clinical Trials Group (ACTG) A5230.
(Clin Infect Dis, 2015-05-15)
BACKGROUND: The AIDS Clinical Trials Group (ACTG) A5230 study evaluated lopinavir/ritonavir
(LPV/r) monotherapy following virologic failure (VF) on first-line human immunodeficiency
virus (HIV) regimens in Africa and Asia. ...
Plerixafor (a CXCR4 antagonist) following myeloablative allogeneic hematopoietic stem cell transplantation enhances hematopoietic recovery.
(J Hematol Oncol, 2018-03-04)
BACKGROUND: The binding of CXCR4 with its ligand (stromal-derived factor-1) maintains
hematopoietic stem/progenitor cells (HSPCs) in a quiescent state. We hypothesized
that blocking CXCR4/SDF-1 interaction after hematopoietic ...
Traditional medicine practices among community members with chronic kidney disease in northern Tanzania: an ethnomedical survey.
(BMC Nephrol, 2015-10-23)
BACKGROUND: In sub-Saharan Africa, chronic kidney disease (CKD) is being recognized
as a non-communicable disease (NCD) with high morbidity and mortality. In countries
like Tanzania, people access many sources, including ...
Differential developmental trajectories of magnetic susceptibility in human brain gray and white matter over the lifespan.
(Hum Brain Mapp, 2014-06)
As indicated by several recent studies, magnetic susceptibility of the brain is influenced
mainly by myelin in the white matter and by iron deposits in the deep nuclei. Myelination
and iron deposition in the brain evolve ...