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Schistosome-induced cholangiocyte proliferation and osteopontin secretion correlate with fibrosis and portal hypertension in human and murine schistosomiasis mansoni.

Andrade, ZA; Chan, IS; Choi, SS; Diehl, Anna Mae; Lambertucci, JR; Machado, MV; Otoni, A; ... (19 authors) (Clin Sci (Lond), 2015-11)

Schistosomiasis is a major cause of portal hypertension worldwide. It associates with portal fibrosis that develops during chronic infection. The mechanisms by which the pathogen evokes these host responses remain unclear. ...

Design of a Novel Low Cost Point of Care Tampon (POCkeT) Colposcope for Use in Resource Limited Settings.

Asma, B; Gallagher, Jennifer E; Krieger, MS; Lam, CT; Muasher, LC; Ramanujam, Nimmi; Schmitt, JW (PLoS One, 2015)

INTRODUCTION: Current guidelines by WHO for cervical cancer screening in low- and middle-income countries involves visual inspection with acetic acid (VIA) of the cervix, followed by treatment during the same visit or a ...

Polymorphisms in Fibronectin Binding Proteins A and B among Staphylococcus aureus Bloodstream Isolates Are Not Associated with Arthroplasty Infection.

Eichenberger, EM; Fowler, Vance Garrison Jr; Hos, NJ; Kaasch, AJ; Kern, WV; Lower, SK; Park, Lawrence P; ... (13 authors) (PLoS One, 2015)

BACKGROUND: Nonsynonymous single nucleotide polymorphisms (SNPs) in fibronectin binding protein A (fnbA) of Staphylococcus aureus are associated with cardiac device infections. However, the role of fnbA SNPs in S. aureus ...

Poor Positive Predictive Value of Lyme Disease Serologic Testing in an Area of Low Disease Incidence.

Auwaerter, PG; Boggan, Joel; Branda, JA; Chudgar, Saumil; Fowler, Vance Garrison Jr; Lantos, Paul; Nigrovic, LE; ... (9 authors) (Clin Infect Dis, 2015-11-01)

BACKGROUND: Lyme disease is diagnosed by 2-tiered serologic testing in patients with a compatible clinical illness, but the significance of positive test results in low-prevalence regions has not been investigated. METHODS: ...

TNF rs1799964 as a Predictive Factor of Acute Toxicities in Chinese Rectal Cancer Patients Treated With Chemoradiotherapy.

Wei, Qingyi; Zhang, Hui; Wang, Mengyun; Shi, Tingyan; Shen, Lijun; Liang, Liping; Deng, Yun; ... (13 authors) (Medicine, 2015-11)

Acute toxicity is the main dose-limiting factor in the chemoradiotherapy of rectal cancer patients and depends on several pro-inflammatory factors, including interleukin-1 (IL-1), IL-6, and tumor necrosis factor-alpha (TNF-α). ...

Substance use and mental diagnoses among adults with and without type 2 diabetes: Results from electronic health records data.

Batch, Bryan; Wu, Li-Tzy; Pencina, Michael; Goldstein, Benjamin; Rusincovitch, Shelley; Ghitza, Udi E; Rojas, Leoncio Flavio; ... (10 authors) (Drug and alcohol dependence, 2015-11)

BACKGROUND:Comorbid diabetes and substance use diagnoses (SUD) represent a hazardous combination, both in terms of healthcare cost and morbidity. To date, there is limited information about the association of SUD and related ...