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Genetic variants of p27 and p21 as predictors for risk of second primary malignancy in patients with index squamous cell carcinoma of head and neck.
(Molecular cancer, 2012-03-26)
Cell cycle deregulation is common in human cancer, and alterations of p27 and p21,
two critical cell cycle regulators, have been implicated in the development of many
human malignancies. Therefore, we hypothesize that p27 ...
Association of tumor necrosis factor-alpha promoter variants with risk of HPV-associated oral squamous cell carcinoma.
(Molecular cancer, 2013-07-19)
Tumor necrosis factor alpha (TNF-α) plays an important role in inflammation, immunity,
and defense against infection and clearance of human papillomavirus (HPV). Thus, genetic
variants may modulate individual susceptibility ...
MicroRNA variants increase the risk of HPV-associated squamous cell carcinoma of the oropharynx in never smokers.
(PloS one, 2013-01)
Both microRNAs and human papillomavirus (HPV) infection play an important role in
the development and progression of oral squamous cell carcinoma (OSCC). In addition,
microRNAs affect all facets of the immune/inflammation ...
Site disparities in apoptotic variants as predictors of risk for second primary malignancy in patients with squamous cell carcinoma of the head and neck.
(BMC cancer, 2016-02-08)
FAS/FASL promoter variants are considered in altering transcriptional activity of
those genes and consequently alter regulation of cell death. However, no studies have
investigated whether tumor sites contribute ...
Association of combined p73 and p53 genetic variants with tumor HPV16-positive oropharyngeal cancer.
(PloS one, 2012-01)
p53 and p73 interact with human papillomavirus (HPV) E6 and E7 oncoproteins. The interplay
between p53 and p73 and HPV16 may lead to deregulation of cell cycle and apoptosis,
through which inflammation/immune responses control ...
Genetic variation in MDM2 and p14ARF and susceptibility to salivary gland carcinoma.
(PloS one, 2012-01)
The p14(ARF)/MDM2/p53 pathway plays an important role in modulation of DNA damage
and oxidative stress responses. The aim of this study was to determine whether genetic
variants in MDM2 and p14(ARF) are associated with risk ...